CDC34

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Cell division cycle 34
Protein CDC34 PDB 2ob4.png
PDB rendering based on 2ob4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CDC34 ; E2-CDC34; UBC3; UBCH3; UBE2R1
External IDs OMIM116948 MGI102657 HomoloGene55815 GeneCards: CDC34 Gene
EC number 6.3.2.19
RNA expression pattern
PBB GE CDC34 212540 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 997 216150
Ensembl ENSG00000099804 ENSMUSG00000020307
UniProt P49427 Q8CFI2
RefSeq (mRNA) NM_004359 NM_177613
RefSeq (protein) NP_004350 NP_808281
Location (UCSC) Chr 19:
0.53 – 0.54 Mb
Chr 10:
79.68 – 79.69 Mb
PubMed search [1] [2]

CDC34 is a gene encoding a protein product that has ubiquitin conjugating activity. CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. Cdc34 in yeast targets numerous substrates (Sic1, Far1, Cln1, Cln2) for ubiquitin mediated degradation. Ubiquitin-conjugating enzyme E2 R1 is a protein that in humans is encoded by the CDC34 gene.[1][2][3]

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[3]

Interactions[edit]

CDC34 has been shown to interact with CSNK2B,[4] BTRC[5][6] and CDK9.[7]

References[edit]

  1. ^ Plon SE, Leppig KA, Do HN, Groudine M (Dec 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proc Natl Acad Sci U S A 90 (22): 10484–8. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134. 
  2. ^ Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ (Oct 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proc Natl Acad Sci U S A 102 (42): 15053–8. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246. 
  3. ^ a b "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)". 
  4. ^ Block, K; Boyer T G; Yew P R (Nov 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". J. Biol. Chem. (United States) 276 (44): 41049–58. doi:10.1074/jbc.M106453200. ISSN 0021-9258. PMID 11546811. 
  5. ^ Semplici, Francesca; Meggio Flavio; Pinna Lorenzo A; Oliviero Salvatore (Jun 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene (England) 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. ISSN 0950-9232. PMID 12037680. 
  6. ^ Cenciarelli, C; Chiaur D S; Guardavaccaro D; Parks W; Vidal M; Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. (ENGLAND) 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. ISSN 0960-9822. PMID 10531035. 
  7. ^ Kiernan, R E; Emiliani S; Nakayama K; Castro A; Labbé J C; Lorca T; Nakayama Ki K; Benkirane M (Dec 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. (United States) 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. ISSN 0270-7306. PMC 99964. PMID 11689688. 

Further reading[edit]