CDC42

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Cell division cycle 42 (GTP binding protein, 25kDa)

PDB rendering based on 1a4r.
Identifiers
Symbols CDC42; CDC42Hs; G25K
External IDs OMIM: 116952 MGI: 106211 HomoloGene: 124410 GeneCards: CDC42 Gene
RNA expression pattern
PBB GE CDC42 208728 s at tn.png
PBB GE CDC42 208727 s at tn.png
PBB GE CDC42 210232 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 998 12540
Ensembl ENSG00000070831 ENSMUSG00000006699
UniProt P60953 Q99JI7
RefSeq (mRNA) NM_001039802.1 NM_009861
RefSeq (protein) NP_001034891.1 NP_033991
Location (UCSC) Chr 1:
22.38 – 22.42 Mb		 Chr 4:
136.59 – 136.63 Mb
PubMed search [1] [2]

Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.[1][2]

Contents

[edit] Function

CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.[3]

[edit] Interactions

CDC42 has been shown to interact with Phospholipase D1,[4] ARHGAP1,[5][6][7][8] PAK7,[9][10] CDC42EP3,[11][12] PARD6B,[13][14][15] ERRFI1,[16] BNIPL,[17] PAK1,[18][8] ARHGDIA,[19][20] PAK2,[21][22][8] WASL,[23][24] GDI1,[25] CDC42EP2,[26][12] BNIP2,[27][28][7] PARD6A,[14][29][15] IQGAP2,[30] IQGAP1,[31][32][33][34][8] ITSN1,[35][36] TRIP10,[37][38] MAP3K11,[5][39] MAP3K10,[5] BAIAP2,[40][41][42] Wiskott-Aldrich syndrome protein,[38][43][44][45] RICS[46][47][48] and PAK4.[19][9][22]

[edit] References

  1. ^ Shinjo K, Koland JG, Hart MJ, Narasimhan V, Johnson DI, Evans T, Cerione RA (December 1990). "Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9853–7. doi:10.1073/pnas.87.24.9853. PMC 55272. PMID 2124704. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55272. 
  2. ^ Munemitsu S, Innis MA, Clark R, McCormick F, Ullrich A, Polakis P (November 1990). "Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42". Mol. Cell. Biol. 10 (11): 5977–82. PMC 361395. PMID 2122236. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=361395. 
  3. ^ "Entrez Gene: CDC42 cell division cycle 42 (GTP binding protein, 25kDa)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=998. 
  4. ^ Walker, S J; Wu W J, Cerione R A, Brown H A (May. 2000). "Activation of phospholipase D1 by Cdc42 requires the Rho insert region". J. Biol. Chem. (UNITED STATES) 275 (21): 15665–8. doi:10.1074/jbc.M000076200. ISSN 0021-9258. PMID 10747870. 
  5. ^ a b c Nagata, K i; Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (Jan. 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. (ENGLAND) 17 (1): 149–58. doi:10.1093/emboj/17.1.149. ISSN 0261-4189. PMC 1170366. PMID 9427749. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170366. 
  6. ^ Li, R; Zhang B, Zheng Y (Dec. 1997). "Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190". J. Biol. Chem. (UNITED STATES) 272 (52): 32830–5. doi:10.1074/jbc.272.52.32830. ISSN 0021-9258. PMID 9407060. 
  7. ^ a b Low, B C; Lim Y P, Lim J, Wong E S, Guy G R (Nov. 1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. (UNITED STATES) 274 (46): 33123–30. doi:10.1074/jbc.274.46.33123. ISSN 0021-9258. PMID 10551883. 
  8. ^ a b c d Zhang, B; Chernoff J, Zheng Y (Apr. 1998). "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA". J. Biol. Chem. (UNITED STATES) 273 (15): 8776–82. doi:10.1074/jbc.273.15.8776. ISSN 0021-9258. PMID 9535855. 
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  24. ^ Miki, H; Sasaki T, Takai Y, Takenawa T (Jan. 1998). "Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP". Nature (ENGLAND) 391 (6662): 93–6. doi:10.1038/34208. ISSN 0028-0836. PMID 9422512. 
  25. ^ Gibson, R M; Wilson-Delfosse A L (Oct. 2001). "RhoGDI-binding-defective mutant of Cdc42Hs targets to membranes and activates filopodia formation but does not cycle with the cytosol of mammalian cells". Biochem. J. (England) 359 (Pt 2): 285–94. doi:10.1042/0264-6021:3590285. ISSN 0264-6021. PMC 1222146. PMID 11583574. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222146. 
  26. ^ Hirsch, D S; Pirone D M, Burbelo P D (Jan. 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J. Biol. Chem. (United States) 276 (2): 875–83. doi:10.1074/jbc.M007039200. ISSN 0021-9258. PMID 11035016. 
  27. ^ Low, B C; Seow K T, Guy G R (May. 2000). "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2". J. Biol. Chem. (UNITED STATES) 275 (19): 14415–22. doi:10.1074/jbc.275.19.14415. ISSN 0021-9258. PMID 10799524. 
  28. ^ Low, B C; Seow K T, Guy G R (Dec. 2000). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. (UNITED STATES) 275 (48): 37742–51. doi:10.1074/jbc.M004897200. ISSN 0021-9258. PMID 10954711. 
  29. ^ Qiu, R G; Abo A, Steven Martin G (Jun. 2000). "A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation". Curr. Biol. (ENGLAND) 10 (12): 697–707. doi:10.1016/S0960-9822(00)00535-2. ISSN 0960-9822. PMID 10873802. 
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  32. ^ Fukata, Masaki; Watanabe Takashi, Noritake Jun, Nakagawa Masato, Yamaga Masaki, Kuroda Shinya, Matsuura Yoshiharu, Iwamatsu Akihiro, Perez Franck, Kaibuchi Kozo (Jun. 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell (United States) 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. ISSN 0092-8674. PMID 12110184. 
  33. ^ Hart, M J; Callow M G, Souza B, Polakis P (Jun. 1996). "IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs". EMBO J. (ENGLAND) 15 (12): 2997–3005. ISSN 0261-4189. PMC 450241. PMID 8670801. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=450241. 
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[edit] Further reading

[edit] External links

Stub icon This hydrolase article is a stub. You can help Wikipedia by expanding it.
3.6.1
3.6.2
3.6.3-4: ATPase
3.6.3
Cu++ (3.6.3.4)
Ca+ (3.6.3.8)
Na+/K+ (3.6.3.9)
ATP1A1 · ATP1A2 · ATP1A3 · ATP1A4 · ATP1B1 · ATP1B2 · ATP1B3 · ATP1B4
H+/K+ (3.6.3.10)
ATP8B1 · ATP10A · ATP11B · ATP12A · ATP13A2 · ATP13A3 ·
3.6.4
3.6.5: GTPase

Rho family of GTPases: Cdc42 (CDC42, TC10, TCL) • RhoUV (RhoU, RhoV) • Rac (Rac1, 2, 3, RhoG) • RhoBTB (1, 2) • RhoH • Rho (A, B, C) • Rnd (1, 2, 3) • RhoDF (RhoF, RhoD)

other: Ras (HRAS, KRAS, NRAS) · Rab (RAB23, RAB27) · Arf (ARF6, SAR1B, ARL13B, ARL6) · Ran · Rheb · Rap
Cyclin
A (A1, A2) · B (B1, B2, B3) · D (D1, D2, D3) · E (E1, E2)
CDK
2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · CDK-activating kinase
CDK inhibitor
P53 p63 p73 family
p53 · p63 · p73
Phases and
checkpoints
Other cellular phases
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
3.6.1
3.6.2
3.6.3-4: ATPase
3.6.3
Cu++ (3.6.3.4)
Ca+ (3.6.3.8)
Na+/K+ (3.6.3.9)
ATP1A1 · ATP1A2 · ATP1A3 · ATP1A4 · ATP1B1 · ATP1B2 · ATP1B3 · ATP1B4
H+/K+ (3.6.3.10)
ATP8B1 · ATP10A · ATP11B · ATP12A · ATP13A2 · ATP13A3 ·
3.6.4
3.6.5: GTPase

Rho family of GTPases: Cdc42 (CDC42, TC10, TCL) • RhoUV (RhoU, RhoV) • Rac (Rac1, 2, 3, RhoG) • RhoBTB (1, 2) • RhoH • Rho (A, B, C) • Rnd (1, 2, 3) • RhoDF (RhoF, RhoD)

other: Ras (HRAS, KRAS, NRAS) · Rab (RAB23, RAB27) · Arf (ARF6, SAR1B, ARL13B, ARL6) · Ran · Rheb · Rap


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