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CDC42 binding protein kinase alpha (DMPK-like)
Symbols CDC42BPA ; MRCK; MRCKA; PK428
External IDs OMIM603412 MGI2441841 HomoloGene55765 ChEMBL: 4516 GeneCards: CDC42BPA Gene
EC number
RNA expression pattern
PBB GE CDC42BPA 203794 at tn.png
PBB GE CDC42BPA 213595 s at tn.png
PBB GE CDC42BPA 214464 at tn.png
More reference expression data
Species Human Mouse
Entrez 8476 226751
Ensembl ENSG00000143776 ENSMUSG00000026490
UniProt Q5VT25 Q3UU96
RefSeq (mRNA) NM_003607 NM_001033285
RefSeq (protein) NP_003598 NP_001028457
Location (UCSC) Chr 1:
227.18 – 227.51 Mb
Chr 1:
179.96 – 180.17 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.[1]

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.[1]


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