CDC42EP1

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CDC42 effector protein (Rho GTPase binding) 1
Identifiers
Symbols CDC42EP1 ; BORG5; CEP1; MSE55
External IDs OMIM606084 MGI1929763 HomoloGene5128 GeneCards: CDC42EP1 Gene
RNA expression pattern
PBB GE CDC42EP1 204693 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11135 104445
Ensembl ENSG00000128283 ENSMUSG00000049521
UniProt Q00587 Q91W92
RefSeq (mRNA) NM_152243 NM_027219
RefSeq (protein) NP_689449 NP_081495
Location (UCSC) Chr 22:
37.96 – 37.97 Mb
Chr 15:
78.84 – 78.85 Mb
PubMed search [1] [2]

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.[1][2][3]

CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. The encoded protein, which is secreted, is primarily found in bone marrow. Two transcript variants encoding different isoforms have been found for this gene.[3]

References[edit]

  1. ^ Bahou WF, Campbell AD, Wicha MS (Aug 1992). "cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression". J Biol Chem 267 (20): 13986–92. PMID 1629197. 
  2. ^ Burbelo PD, Snow DM, Bahou W, Spiegel S (Sep 1999). "MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts". Proc Natl Acad Sci U S A 96 (16): 9083–8. doi:10.1073/pnas.96.16.9083. PMC 17736. PMID 10430899. 
  3. ^ a b "Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1". 

Further reading[edit]