CDCP1

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CUB domain containing protein 1
Identifiers
Symbols CDCP1 ; CD318; SIMA135; TRASK
External IDs OMIM611735 MGI2442010 HomoloGene11276 GeneCards: CDCP1 Gene
RNA expression pattern
PBB GE CDCP1 218451 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64866 109332
Ensembl ENSG00000163814 ENSMUSG00000035498
UniProt Q9H5V8 Q5U462
RefSeq (mRNA) NM_022842 NM_133974
RefSeq (protein) NP_073753 NP_598735
Location (UCSC) Chr 3:
45.12 – 45.19 Mb
Chr 9:
123.17 – 123.22 Mb
PubMed search [1] [2]

CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene.[1][2] CDCP1 has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]

Function[edit]

CDCP1/Trask is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. The tyrosine phosphorylation of Trask is tightly regulated and reciprocally linked with the state of cell adhesion.[3] The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion.

Clinical significance[edit]

The phosphorylation of CDCP1 is seen in many cancers, including some pre-invasive cancers as well as in invasive tumors and in tumor metastases. The functional implications of CDCP1 phosphorylation in tumors is currently under investigation.

References[edit]

  1. ^ Scherl-Mostageer M, Sommergruber W, Abseher R, Hauptmann R, Ambros P, Schweifer N (Jul 2001). "Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer". Oncogene 20 (32): 4402–8. doi:10.1038/sj.onc.1204566. PMID 11466621. 
  2. ^ a b "Entrez Gene: CDCP1 CUB domain containing protein 1". 
  3. ^ Spassov DS, Ahuja D, Wong CH, Moasser MM (2011). "The structural features of trask that mediate its anti-adhesive functions". PLoS ONE 6 (4): e19154. doi:10.1371/journal.pone.0019154. PMC 3084758. PMID 21559459. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.