This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Gyapay G, Morissette J, Vignal A et al. (1994). "The 1993-94 Généthon human genetic linkage map". Nat. Genet.7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID7545953.CS1 maint: Explicit use of et al. (link)
Tanihara H, Sano K, Heimark RL et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin". Cell Adhes. Commun.2 (1): 15–26. doi:10.3109/15419069409014199. PMID7982033.CS1 maint: Explicit use of et al. (link)
Kremmidiotis G, Baker E, Crawford J et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID9615235.CS1 maint: Explicit use of et al. (link)
Chalmers IJ, Höfler H, Atkinson MJ (1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID10191097.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.CS1 maint: Explicit use of et al. (link)