CDH6

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cadherin 6, type 2, K-cadherin (fetal kidney)
Identifiers
Symbols CDH6 ; CAD6; KCAD
External IDs OMIM603007 MGI107435 HomoloGene21027 GeneCards: CDH6 Gene
RNA expression pattern
PBB GE CDH6 205532 s at tn.png
PBB GE CDH6 205533 s at tn.png
PBB GE CDH6 210602 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1004 12563
Ensembl ENSG00000113361 ENSMUSG00000039385
UniProt P55285 P97326
RefSeq (mRNA) NM_004932 NM_007666
RefSeq (protein) NP_004923 NP_031692
Location (UCSC) Chr 5:
31.19 – 31.33 Mb
Chr 15:
13.03 – 13.17 Mb
PubMed search [1] [2]

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.[1][2][3]

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.[3]

References[edit]

  1. ^ Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (Jun 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res 55 (10): 2206–11. PMID 7743525. 
  2. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097. 
  3. ^ a b "Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)". 

Further reading[edit]

External links[edit]