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Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Protein CDKN2C PDB 1bu9.png
PDB rendering based on 1bu9.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CDKN2C ; INK4C; p18; p18-INK4C
External IDs OMIM603369 MGI105388 HomoloGene966 GeneCards: CDKN2C Gene
RNA expression pattern
PBB GE CDKN2C 204159 at tn.png
PBB GE CDKN2C 211792 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1031 12580
Ensembl ENSG00000123080 ENSMUSG00000028551
UniProt P42773 Q60772
RefSeq (mRNA) NM_001262 NM_007671
RefSeq (protein) NP_001253 NP_031697
Location (UCSC) Chr 1:
51.43 – 51.44 Mb
Chr 4:
109.66 – 109.67 Mb
PubMed search [1] [2]

Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.[1][2][3]

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.[3]


CDKN2C has been shown to interact with Cyclin-dependent kinase 4[1][4] and Cyclin-dependent kinase 6.[1][4][5]


  1. ^ a b c Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y (January 1995). "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function". Genes Dev 8 (24): 2939–52. doi:10.1101/gad.8.24.2939. PMID 8001816. 
  2. ^ Blais A, Labrie Y, Pouliot F, Lachance Y, Labrie C (July 1998). "Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer". Biochem Biophys Res Commun 247 (1): 146–53. doi:10.1006/bbrc.1998.8497. PMID 9636670. 
  3. ^ a b "Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)". 
  4. ^ a b Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ Jeffrey, P D; Tong L; Pavletich N P (December 2000). "Structural basis of inhibition of CDK–cyclin complexes by INK4 inhibitors". Genes Dev. (UNITED STATES) 14 (24): 3115–25. doi:10.1101/gad.851100. ISSN 0890-9369. PMC 317144. PMID 11124804. 

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