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Cell adhesion associated, oncogene regulated
Protein CDON PDB 3D1M.png
Rendering based on PDB 3D1M.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM608707 MGI1926387 HomoloGene22996 GeneCards: CDON Gene
RNA expression pattern
PBB GE CDON 207230 at tn.png
More reference expression data
Species Human Mouse
Entrez 50937 57810
Ensembl ENSG00000064309 ENSMUSG00000038119
UniProt Q4KMG0 Q32MD9
RefSeq (mRNA) NM_001243597 NM_021339
RefSeq (protein) NP_001230526 NP_067314
Location (UCSC) Chr 11:
125.83 – 125.93 Mb
Chr 9:
35.42 – 35.51 Mb
PubMed search [1] [2]

Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.[1][2]

CDON and BOC (MIM 608708) are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM][2]


CDON has been shown to interact with CDH1[3] and BOC.[4]


  1. ^ Kang JS, Gao M, Feinleib JL, Cotter PD, Guadagno SN, Krauss RS (Aug 1997). "CDO: An Oncogene-, Serum-, and Anchorage-regulated Member of the Ig/Fibronectin Type III Repeat Family". J Cell Biol 138 (1): 203–13. doi:10.1083/jcb.138.1.203. PMC 2139939. PMID 9214393. 
  2. ^ a b "Entrez Gene: CDON Cdon homolog (mouse)". 
  3. ^ Kang, Jong-Sun; Feinleib Jessica L; Knox Sarah; Ketteringham Michael A; Krauss Robert S (Apr 2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (7): 3989–94. doi:10.1073/pnas.0736565100. ISSN 0027-8424. PMC 153035. PMID 12634428. 
  4. ^ Kang, Jong-Sun; Mulieri Philip J; Hu Yulan; Taliana Lavinia; Krauss Robert S (Jan 2002). "BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation". EMBO J. (England) 21 (1–2): 114–24. doi:10.1093/emboj/21.1.114. ISSN 0261-4189. PMC 125805. PMID 11782431. 

Further reading[edit]