CDON

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Cell adhesion associated, oncogene regulated
Protein CDON PDB 3D1M.png
Rendering based on PDB 3D1M.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CDON ; CDO; CDON1; HPE11; ORCAM
External IDs OMIM608707 MGI1926387 HomoloGene22996 GeneCards: CDON Gene
RNA expression pattern
PBB GE CDON 207230 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 50937 57810
Ensembl ENSG00000064309 ENSMUSG00000038119
UniProt Q4KMG0 Q32MD9
RefSeq (mRNA) NM_001243597 NM_021339
RefSeq (protein) NP_001230526 NP_067314
Location (UCSC) Chr 11:
125.83 – 125.93 Mb
Chr 9:
35.42 – 35.51 Mb
PubMed search [1] [2]

Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.[1][2]

CDON and BOC (MIM 608708) are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM][2]

Interactions[edit]

CDON has been shown to interact with CDH1[3] and BOC.[4]

References[edit]

  1. ^ Kang JS, Gao M, Feinleib JL, Cotter PD, Guadagno SN, Krauss RS (Aug 1997). "CDO: An Oncogene-, Serum-, and Anchorage-regulated Member of the Ig/Fibronectin Type III Repeat Family". J Cell Biol 138 (1): 203–13. doi:10.1083/jcb.138.1.203. PMC 2139939. PMID 9214393. 
  2. ^ a b "Entrez Gene: CDON Cdon homolog (mouse)". 
  3. ^ Kang, Jong-Sun; Feinleib Jessica L; Knox Sarah; Ketteringham Michael A; Krauss Robert S (Apr 2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (7): 3989–94. doi:10.1073/pnas.0736565100. ISSN 0027-8424. PMC 153035. PMID 12634428. 
  4. ^ Kang, Jong-Sun; Mulieri Philip J; Hu Yulan; Taliana Lavinia; Krauss Robert S (Jan 2002). "BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation". EMBO J. (England) 21 (1–2): 114–24. doi:10.1093/emboj/21.1.114. ISSN 0261-4189. PMC 125805. PMID 11782431. 

Further reading[edit]