CEACAM1

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Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Protein CEACAM1 PDB 2gk2.png
PDB rendering based on 2gk2.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CEACAM1 ; BGP; BGP1; BGPI
External IDs OMIM109770 MGI1347245 HomoloGene128630 GeneCards: CEACAM1 Gene
RNA expression pattern
PBB GE CEACAM1 206576 s at tn.png
PBB GE CEACAM1 209498 at tn.png
PBB GE CEACAM1 211883 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 634 26365
Ensembl ENSG00000079385 ENSMUSG00000074272
UniProt P13688 P31809
RefSeq (mRNA) NM_001024912 NM_001039185
RefSeq (protein) NP_001020083 NP_001034274
Location (UCSC) Chr 19:
43.01 – 43.07 Mb
Chr 7:
25.46 – 25.48 Mb
PubMed search [1] [2]

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human glycoprotein, encoded by a gene.[1]

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.[1]

In melanocytic cells CEACAM1 gene expression may be regulated by MITF.[2]

Interactions[edit]

CEACAM1 has been shown to interact with PTPN11[3] and Annexin A2.[4]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)". 
  2. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  3. ^ Huber, M; Izzi L; Grondin P; Houde C; Kunath T; Veillette A; Beauchemin N (Jan 1999). "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". J. Biol. Chem. (UNITED STATES) 274 (1): 335–44. doi:10.1074/jbc.274.1.335. ISSN 0021-9258. PMID 9867848. 
  4. ^ Kirshner, Julia; Schumann Detlef; Shively John E (Dec 2003). "CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis". J. Biol. Chem. (United States) 278 (50): 50338–45. doi:10.1074/jbc.M309115200. ISSN 0021-9258. PMID 14522961. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.