Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human glycoprotein, encoded by a gene.
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.
In melanocytic cells CEACAM1 gene expression may be regulated by MITF.
^Huber, M; Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N (Jan. 1999). "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". J. Biol. Chem. (UNITED STATES) 274 (1): 335–44. doi:10.1074/jbc.274.1.335. ISSN0021-9258. PMID9867848.
^Kirshner, Julia; Schumann Detlef, Shively John E (Dec. 2003). "CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis". J. Biol. Chem. (United States) 278 (50): 50338–45. doi:10.1074/jbc.M309115200. ISSN0021-9258. PMID14522961.
Gray-Owen SD, Blumberg RS (2006). "CEACAM1: contact-dependent control of immunity.". Nat. Rev. Immunol.6 (6): 433–46. doi:10.1038/nri1864. PMID16724098.
Svenberg T, Hammarström S, Zeromski J (1979). "Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues". Clin. Exp. Immunol.36 (3): 436–41. PMC1537745. PMID385181.
Thompson J, Zimmermann W, Osthus-Bugat P, et al. (1992). "Long-range chromosomal mapping of the carcinoembryonic antigen (CEA) gene family cluster". Genomics12 (4): 761–72. doi:10.1016/0888-7543(92)90307-E. PMID1572649.
Kuroki M, Arakawa F, Matsuo Y, et al. (1991). "Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library". Biochem. Biophys. Res. Commun.176 (2): 578–85. doi:10.1016/S0006-291X(05)80223-2. PMID2025273.
Hinoda Y, Neumaier M, Hefta SA, et al. (1988). "Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen". Proc. Natl. Acad. Sci. U.S.A.85 (18): 6959–63. doi:10.1073/pnas.85.18.6959. PMC282098. PMID2457922.
Barnett TR, Kretschmer A, Austen DA, et al. (1989). "Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family". J. Cell Biol.108 (2): 267–76. doi:10.1083/jcb.108.2.267. PMC2115422. PMID2537311.
Neumaier M, Paululat S, Chan A, et al. (1993). "Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas". Proc. Natl. Acad. Sci. U.S.A.90 (22): 10744–8. doi:10.1073/pnas.90.22.10744. PMC47854. PMID7504281.
Formisano P, Najjar SM, Gross CN, et al. (1995). "Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase". J. Biol. Chem.270 (41): 24073–7. doi:10.1074/jbc.270.26.15844. PMID7592607.
Frängsmyr L, Baranov V, Prall F, et al. (1995). "Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa". Cancer Res.55 (14): 2963–7. PMID7606710.
Najjar SM, Philippe N, Suzuki Y, et al. (1995). "Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase". Biochemistry34 (29): 9341–9. doi:10.1021/bi00029a009. PMID7626603.
Nédellec P, Turbide C, Beauchemin N (1995). "Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene". Eur. J. Biochem.231 (1): 104–14. doi:10.1111/j.1432-1033.1995.tb20676.x. PMID7628460.
Watt SM, Fawcett J, Murdoch SJ, et al. (1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant". Blood84 (1): 200–10. PMID8018919.
Hauck W, Nédellec P, Turbide C, et al. (1994). "Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas". Eur. J. Biochem.223 (2): 529–41. doi:10.1111/j.1432-1033.1994.tb19022.x. PMID8055923.
Barnett TR, Drake L, Pickle W (1993). "Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins". Mol. Cell. Biol.13 (2): 1273–82. PMC359012. PMID8423792.
Kuroki M, Yamanaka T, Matsuo Y, et al. (1996). "Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils". Immunol. Invest.24 (5): 829–43. doi:10.3109/08820139509060710. PMID8543346.
Huber M, Izzi L, Grondin P, et al. (1999). "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". J. Biol. Chem.274 (1): 335–44. doi:10.1074/jbc.274.1.335. PMID9867848.
Feuk-Lagerstedt E, Jordan ET, Leffler H, et al. (1999). "Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils". J. Immunol.163 (10): 5592–8. PMID10553088.
Soni P, Lakkis M, Poy MN, et al. (2000). "The Differential Effects of pp120 (Ceacam 1) on the Mitogenic Action of Insulin and Insulin-Like Growth Factor 1 Are Regulated by the Nonconserved Tyrosine 1316 in the Insulin Receptor". Mol. Cell. Biol.20 (11): 3896–905. doi:10.1128/MCB.20.11.3896-3905.2000. PMC85733. PMID10805733.
Ergün S, Kilik N, Ziegeler G, et al. (2000). "CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor". Mol. Cell5 (2): 311–20. doi:10.1016/S1097-2765(00)80426-8. PMID10882072.
Wang L, Lin SH, Wu WG, et al. (2000). "C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers". Clin. Cancer Res.6 (8): 2988–93. PMID10955775.