CEACAM3

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Carcinoembryonic antigen-related cell adhesion molecule 3
Identifiers
Symbols CEACAM3 ; CD66D; CEA; CGM1; W264; W282
External IDs OMIM609142 MGI1347248 HomoloGene130497 GeneCards: CEACAM3 Gene
RNA expression pattern
PBB GE CEACAM3 208052 x at tn.png
PBB GE CEACAM3 210789 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1084 26366
Ensembl ENSG00000170956 ENSMUSG00000054169
UniProt P40198 Q61400
RefSeq (mRNA) NM_001277163 NM_007675
RefSeq (protein) NP_001264092 NP_031701
Location (UCSC) Chr 19:
42.3 – 42.32 Mb
Chr 7:
24.49 – 24.49 Mb
PubMed search [1] [2]

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a human gene.[1]

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[1]

Use[edit]

CEACAM3 is expressed exclusively on granulocytes and used as granulocyte marker.[2]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3". 
  2. ^ CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.