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Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
Symbols CEACAM6 ; CD66c; CEAL; NCA
External IDs OMIM163980 HomoloGene130505 GeneCards: CEACAM6 Gene
RNA expression pattern
PBB GE CEACAM6 203757 s at tn.png
PBB GE CEACAM6 211657 at tn.png
More reference expression data
Species Human Mouse
Entrez 4680 n/a
Ensembl ENSG00000086548 n/a
UniProt P40199 n/a
RefSeq (mRNA) NM_002483 n/a
RefSeq (protein) NP_002474 n/a
Location (UCSC) Chr 19:
42.25 – 42.28 Mb
PubMed search [1] n/a

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known as CD66c (Cluster of Differentiation 66c), is a human gene.[1]

See also[edit]


Further reading[edit]

  • Oikawa S, Inuzuka C, Kuroki M et al. (1991). "A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains.". J. Biol. Chem. 266 (13): 7995–8001. PMID 2022629. 
  • Haus O, Noworolska A, Laskowski M et al. (1990). "Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia.". Exp. Mol. Pathol. 52 (2): 235–42. doi:10.1016/0014-4800(90)90008-2. PMID 2332039. 
  • Hefta SA, Paxton RJ, Shively JE (1990). "Sequence and glycosylation site identity of two distinct glycoforms of nonspecific cross-reacting antigen as demonstrated by sequence analysis and fast atom bombardment mass spectrometry.". J. Biol. Chem. 265 (15): 8618–26. PMID 2341397. 
  • Inazawa J, Abe T, Inoue K et al. (1990). "Regional assignment of nonspecific cross-reacting antigen (NCA) of the CEA gene family to chromosome 19 at band q13.2.". Cytogenet. Cell Genet. 52 (1–2): 28–31. doi:10.1159/000132833. PMID 2612212. 
  • Neumaier M, Zimmermann W, Shively L et al. (1988). "Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen". J. Biol. Chem. 263 (7): 3202–7. PMID 2830274. 
  • Kuroki M, Kuroki M, Moore GE et al. (1988). "The molecular heterogeneity of nonspecific cross-reacting antigen synthesized by tumor cells and granulocytes". Jpn. J. Cancer Res. 79 (1): 82–90. doi:10.1111/j.1349-7006.1988.tb00014.x. PMID 3128509. 
  • Barnett T, Goebel SJ, Nothdurft MA, Elting JJ (1989). "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains". Genomics 3 (1): 59–66. doi:10.1016/0888-7543(88)90160-7. PMID 3220478. 
  • Tawaragi Y, Oikawa S, Matsuoka Y et al. (1988). "Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence". Biochem. Biophys. Res. Commun. 150 (1): 89–96. doi:10.1016/0006-291X(88)90490-1. PMID 3337731. 
  • Noworolska A, Harłozińska-Szmyrka A, Richter R (1986). "Distribution of surface nonspecific cross-reacting antigen and influence of proteolytic enzymes on this antigen in myeloid cell series". Cancer Detect. Prev. 9 (3–4): 365–71. PMID 3527416. 
  • Oikawa S, Kosaki G, Nakazato H (1987). "Molecular cloning of a gene for a member of carcinoembryonic antigen (CEA) gene family; signal peptide and N-terminal domain sequences of nonspecific crossreacting antigen (NCA)". Biochem. Biophys. Res. Commun. 146 (2): 464–9. doi:10.1016/0006-291X(87)90552-3. PMID 3619891. 
  • Watt SM, Fawcett J, Murdoch SJ et al. (1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant". Blood 84 (1): 200–10. PMID 8018919. 
  • Honda Y, Egawa K, Kuroki M, Ono T (1997). "Hair cycle-dependent expression of a nonspecific cross reacting antigen (NCA)-50/90-like molecule on follicular keratinocytes". Arch. Dermatol. Res. 289 (8): 457–65. doi:10.1007/s004030050221. PMID 9266023. 
  • Schölzel S, Zimmermann W, Schwarzkopf G et al. (2000). "Carcinoembryonic Antigen Family Members CEACAM6 and CEACAM7 Are Differentially Expressed in Normal Tissues and Oppositely Deregulated in Hyperplastic Colorectal Polyps and Early Adenomas". Am. J. Pathol. 156 (2): 595–605. doi:10.1016/S0002-9440(10)64764-5. PMC 1850034. PMID 10666389. 
  • Oikawa S, Sugiyama M, Kuroki M et al. (2001). "Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8". Biochem. Biophys. Res. Commun. 278 (3): 564–8. doi:10.1006/bbrc.2000.3858. PMID 11095950. 
  • Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002). "Deregulated Expression of the Human Tumor Marker CEA and CEA Family Member CEACAM6 Disrupts Tissue Architecture and Blocks Colonocyte Differentiation". Neoplasia 4 (2): 151–63. doi:10.1038/sj/neo/7900201. PMC 1550325. PMID 11896570. 
  • Singer BB, Scheffrahn I, Heymann R et al. (2002). "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes". J. Immunol. 168 (10): 5139–46. doi:10.4049/jimmunol.168.10.5139. PMID 11994468. 
  • Skubitz KM, Campbell KD, Skubitz AP (2002). "Synthetic peptides from the N-domains of CEACAMs activate neutrophils". J. Pept. Res. 58 (6): 515–26. doi:10.1034/j.1399-3011.2001.00931.x. PMID 12005421. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Taheri M, Saragovi HU, Stanners CP (2003). "The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked". J. Biol. Chem. 278 (17): 14632–9. doi:10.1074/jbc.M212500200. PMID 12571231. 
  • Duxbury MS, Ito H, Zinner MJ et al. (2004). "CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells". Oncogene 23 (2): 465–73. doi:10.1038/sj.onc.1207036. PMID 14724575. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.