The protein encoded by this gene is a bZIPtranscription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyteprogenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.
^Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (July 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID8661101.
^Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". J. Biol. Chem.281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID16531405.
Williams SC, Cantwell CA, Johnson PF (1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.". Genes Dev.5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID1884998.
Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus.". Genomics35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID8661101.
Verbeek W, Gombart AF, Chumakov AM, et al. (1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.". Blood93 (10): 3327–37. PMID10233885.
Tavor S, Vuong PT, Park DJ, et al. (2002). "Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice.". Blood99 (5): 1794–801. doi:10.1182/blood.V99.5.1794. PMID11861297.
Kim J, Cantwell CA, Johnson PF, et al. (2002). "Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation.". J. Biol. Chem.277 (41): 38037–44. doi:10.1074/jbc.M207235200. PMID12161447.
Du J, Stankiewicz MJ, Liu Y, et al. (2003). "Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein.". J. Biol. Chem.277 (45): 43481–94. doi:10.1074/jbc.M204777200. PMID12202480.
Gombart AF, Kwok SH, Anderson KL, et al. (2003). "Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.". Blood101 (8): 3265–73. doi:10.1182/blood-2002-04-1039. PMID12515729.
Khanna-Gupta A, Zibello T, Sun H, et al. (2003). "Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression.". Blood101 (9): 3460–8. doi:10.1182/blood-2002-09-2767. PMID12522000.