CENPF

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Centromere protein F, 350/400kDa
Identifiers
Symbols CENPF ; CENF; PRO1779; hcp-1
External IDs OMIM600236 MGI1313302 HomoloGene22969 GeneCards: CENPF Gene
Orthologs
Species Human Mouse
Entrez 1063 108000
Ensembl ENSG00000117724 ENSMUSG00000026605
UniProt P49454 E9PY14
RefSeq (mRNA) NM_016343 NM_001081363
RefSeq (protein) NP_057427 NP_001074832
Location (UCSC) Chr 1:
214.78 – 214.84 Mb
Chr 1:
189.64 – 189.69 Mb
PubMed search [1] [2]

Centromere protein F is a protein that in humans is encoded by the CENPF gene.[1][2][3]

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.[3]

References[edit]

  1. ^ Rattner JB, Rao A, Fritzler MJ, Valencia DW, Yen TJ (Mar 1994). "CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization". Cell Motil Cytoskeleton 26 (3): 214–26. doi:10.1002/cm.970260305. PMID 7904902. 
  2. ^ Testa JR, Zhou JY, Bell DW, Yen TJ (Mar 1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization". Genomics 23 (3): 691–3. doi:10.1006/geno.1994.1558. PMID 7851898. 
  3. ^ a b "Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)". 

Further reading[edit]