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ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Symbols ARAP1 ; CENTD2
External IDs OMIM606646 MGI1916960 HomoloGene12326 GeneCards: ARAP1 Gene
Species Human Mouse
Entrez 116985 69710
Ensembl ENSG00000186635 ENSMUSG00000032812
UniProt Q96P48 Q4LDD4
RefSeq (mRNA) NM_001040118 NM_001040111
RefSeq (protein) NP_001035207 NP_001035200
Location (UCSC) Chr 11:
72.4 – 72.5 Mb
Chr 7:
101.35 – 101.41 Mb
PubMed search [1] [2]

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.[1]

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. The RHO-GAP activity may mediate cell rounding and loss of stress fibers. At least three transcript variants encoding different isoforms have been found for this gene, but the full-length natures of all variants have not been determined.[1]


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