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ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARAP3 ; CENTD3; DRAG1
External IDs OMIM606647 MGI2147274 HomoloGene11199 GeneCards: ARAP3 Gene
RNA expression pattern
PBB GE CENTD3 218950 at tn.png
PBB GE CENTD3 gnf1h01471 at tn.png
PBB GE CENTD3 gnf1h07750 at tn.png
More reference expression data
Species Human Mouse
Entrez 64411 106952
Ensembl ENSG00000120318 ENSMUSG00000024451
UniProt Q8WWN8 Q8R5G7
RefSeq (mRNA) NM_022481 NM_001205336
RefSeq (protein) NP_071926 NP_001192265
Location (UCSC) Chr 5:
141.03 – 141.06 Mb
Chr 18:
37.97 – 38 Mb
PubMed search [1] [2]

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.[1][2][3]

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.[3]


  1. ^ Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (Jan 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol Cell 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589. 
  2. ^ Santy LC, Casanova JE (May 2002). "GTPase signaling: bridging the GAP between ARF and Rho". Curr Biol 12 (10): R360–2. doi:10.1016/S0960-9822(02)00860-6. PMID 12015138. 
  3. ^ a b "Entrez Gene: CENTD3 centaurin, delta 3". 

Further reading[edit]