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ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Protein CENTG1 PDB 2bmj.png
PDB rendering based on 2bmj.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM605476 HomoloGene86815 GeneCards: AGAP2 Gene
RNA expression pattern
PBB GE CENTG1 206152 at tn.png
PBB GE CENTG1 215080 s at tn.png
More reference expression data
Species Human Mouse
Entrez 116986 216439
Ensembl ENSG00000135439 ENSMUSG00000025422
UniProt Q99490 Q3UHD9
RefSeq (mRNA) NM_001122772 NM_001033263
RefSeq (protein) NP_001116244 NP_001028435
Location (UCSC) Chr 12:
58.12 – 58.14 Mb
Chr 10:
127.08 – 127.09 Mb
PubMed search [1] [2]

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is an enzyme that in humans is encoded by the AGAP2 gene.[1]


CENTG1 has been shown to interact with PIK3R1,[2] HOMER1[3] and EPB41L1.[2]


  1. ^ "Entrez Gene: CENTG1 centaurin, gamma 1". 
  2. ^ a b Ye, K; Hurt K J; Wu F Y; Fang M; Luo H R; Hong J J; Blackshaw S; Ferris C D; Snyder S H (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell (UNITED STATES) 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. ISSN 0092-8674. PMID 11136977. 
  3. ^ Rong, Rong; Ahn Jee-Yin; Huang Honglian; Nagata Eiichiro; Kalman Daniel; Kapp Judith A; Tu Jiancheng; Worley Paul F; Snyder Solomon H; Ye Keqiang (November 2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. (United States) 6 (11): 1153–61. doi:10.1038/nn1134. ISSN 1097-6256. PMID 14528310. 

Further reading[edit]