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Centrosomal protein 135kDa
Symbols CEP135 ; CEP4; KIAA0635; MCPH8
External IDs OMIM611423 MGI2681869 HomoloGene45709 GeneCards: CEP135 Gene
RNA expression pattern
PBB GE CEP135 206003 at tn.png
More reference expression data
Species Human Mouse
Entrez 9662 381644
Ensembl ENSG00000174799 ENSMUSG00000036403
UniProt Q66GS9 Q6P5D4
RefSeq (mRNA) NM_014645 NM_199032
RefSeq (protein) NP_079285 NP_950197
Location (UCSC) Chr 4:
56.82 – 56.9 Mb
Chr 5:
76.59 – 76.65 Mb
PubMed search [1] [2]

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene.[1][2][3] It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material.[4] CEP135 is required for the centriolar localization of CEP250.[5]


  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. 
  3. ^ "Entrez Gene: CEP135 centrosomal protein 135kDa". 
  4. ^ Ohta T, Essner R, Ryu JH, Palazzo RE, Uetake Y, Kuriyama R (January 2002). "Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells". J. Cell Biol. 156 (1): 87–99. doi:10.1083/jcb.200108088. PMC 2173569. PMID 11781336. 
  5. ^ Kim K, Lee S, Chang J, Rhee K (December 2008). "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization". Exp. Cell Res. 314 (20): 3692–700. doi:10.1016/j.yexcr.2008.09.016. PMID 18851962. 

Further reading[edit]