CEP192

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Centrosomal protein 192kDa
Identifiers
Symbols CEP192 ; PPP1R62
External IDs HomoloGene73526 GeneCards: CEP192 Gene
Orthologs
Species Human Mouse
Entrez 55125 70799
Ensembl ENSG00000101639 ENSMUSG00000024542
UniProt Q8TEP8 n/a
RefSeq (mRNA) NM_018069 NM_027556
RefSeq (protein) NP_115518 NP_081832
Location (UCSC) Chr 18:
12.99 – 13.13 Mb
Chr 18:
67.8 – 67.89 Mb
PubMed search [1] [2]

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene.[1][2] It is the homolog of the C. elegans and D. melanogaster gene SPD-2.[3]

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells.[3] It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.[4]

References[edit]

  1. ^ "Entrez Gene: centrosomal protein 192kDa". 
  2. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. 
  3. ^ a b Zhu, F.; Lawo, S.; Bird, A.; Pinchev, D.; Ralph, A.; Richter, C.; Müller-Reichert, T.; Kittler, R.; Hyman, A.; Pelletier, L. (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Current biology : CB 18 (2): 136–141. doi:10.1016/j.cub.2007.12.055. PMID 18207742.  edit
  4. ^ Gomez-Ferreria, M.; Rath, U.; Buster, D.; Chanda, S.; Caldwell, J.; Rines, D.; Sharp, D. (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly". Current biology : CB 17 (22): 1960–1966. doi:10.1016/j.cub.2007.10.019. PMID 17980596.  edit

Further reading[edit]