CEP350

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Centrosomal protein 350kDa
Protein CEP350 PDB 2coz.png
PDB rendering based on 2coz.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CEP350 ; CAP350; GM133
External IDs MGI1921331 HomoloGene8879 GeneCards: CEP350 Gene
RNA expression pattern
PBB GE CEP350 204373 s at tn.png
PBB GE CEP350 213165 at tn.png
PBB GE CEP350 213956 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9857 74081
Ensembl ENSG00000135837 ENSMUSG00000033671
UniProt Q5VT06 E9Q309
RefSeq (mRNA) NM_014810 NM_001039184
RefSeq (protein) NP_055625 NP_001034273
Location (UCSC) Chr 1:
179.92 – 180.08 Mb
Chr 1:
155.84 – 155.97 Mb
PubMed search [1] [2]

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.[1][2][3]

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.[4]

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[3]


References[edit]

  1. ^ Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring". Mol Biol Cell 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388. 
  2. ^ Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350". J Cell Sci 118 (Pt 1): 175–86. doi:10.1242/jcs.01600. PMID 15615782. 
  3. ^ a b "Entrez Gene: CEP350 centrosomal protein 350kDa". 
  4. ^ Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly.". PLoS ONE 3 (12): e3855. doi:10.1371/journal.pone.0003855. PMC 2586089. PMID 19052644. 

Further reading[edit]