CEP68

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Centrosomal protein 68kDa
Identifiers
Symbols CEP68 ; KIAA0582
External IDs MGI2667663 HomoloGene65235 GeneCards: CEP68 Gene
RNA expression pattern
PBB GE CEP68 207971 s at tn.png
PBB GE CEP68 212675 s at tn.png
PBB GE CEP68 212677 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23177 216543
Ensembl ENSG00000011523 ENSMUSG00000044066
UniProt Q76N32 Q8C0D9
RefSeq (mRNA) NM_015147 NM_172260
RefSeq (protein) NP_055962 NP_758464
Location (UCSC) Chr 2:
65.28 – 65.31 Mb
Chr 11:
20.23 – 20.25 Mb
PubMed search [1] [2]

Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene.[1][2][3][4] CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend both on each other for centriole association, and both also require CEP250 for their function.[5]

References[edit]

  1. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581. 
  2. ^ "Toward a complete human genome sequence". Genome Res 8 (11): 1097–108. Jan 1999. doi:10.1101/gr.8.11.1097. PMID 9847074. 
  3. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. 
  4. ^ "Entrez Gene: CEP68 centrosomal protein 68kDa". 
  5. ^ Graser, S; Stierhof, YD, Nigg, EA (Dec 15, 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion.". Journal of cell science 120 (Pt 24): 4321–31. doi:10.1242/jcs.020248. PMID 18042621. 

Further reading[edit]