CEP70

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Centrosomal protein 70kDa
Identifiers
Symbols CEP70 ; BITE
External IDs OMIM614310 MGI1915371 HomoloGene11387 GeneCards: CEP70 Gene
RNA expression pattern
PBB GE CEP70 219036 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 80321 68121
Ensembl ENSG00000114107 ENSMUSG00000056267
UniProt Q8NHQ1 Q6IQY5
RefSeq (mRNA) NM_024491 NM_023873
RefSeq (protein) NP_077817 NP_076362
Location (UCSC) Chr 3:
138.21 – 138.31 Mb
Chr 9:
99.24 – 99.3 Mb
PubMed search [1] [2]

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene.[1][2] The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.[3]

References[edit]

  1. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. 
  2. ^ "Entrez Gene: CEP70 centrosomal protein 70kDa". 
  3. ^ Shi X, Sun X, Liu M, Li D, Aneja R, Zhou J (September 2011). "CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly". J. Biol. Chem. 286 (38): 33401–8. doi:10.1074/jbc.M111.252262. PMID 21795687. 

Further reading[edit]