Carboxylesterase 2

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Carboxylesterase 2
Identifiers
Symbols CES2 ; CE-2; CES2A1; PCE-2; iCE
External IDs OMIM605278 MGI3648740 HomoloGene128645 ChEMBL: 3180 GeneCards: CES2 Gene
EC number 3.1.1.1, 3.1.1.56, 3.1.1.84
RNA expression pattern
PBB GE CES2 209667 at tn.png
PBB GE CES2 209668 x at tn.png
PBB GE CES2 213509 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8824 436059
Ensembl ENSG00000172831 ENSMUSG00000091813
UniProt O00748 Q91WG0
RefSeq (mRNA) NM_003869 NM_001272045
RefSeq (protein) NP_003860 NP_001258974
Location (UCSC) Chr 16:
66.97 – 66.98 Mb
Chr 8:
105 – 105.02 Mb
PubMed search [1] [2]

Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene.[1][2][3] It is a member of the alpha/beta fold hydrolase family.[4]

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
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|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit|]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". 
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
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|{{{bSize}}}px|alt=Irinotecan Pathway edit|]]
  1. ^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359". 

References[edit]

  1. ^ Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF (Jun 1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". J Biol Chem 272 (23): 14769–75. doi:10.1074/jbc.272.23.14769. PMID 9169443. 
  2. ^ Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G (Jun 1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochem Biophys Res Commun 233 (1): 117–20. doi:10.1006/bbrc.1997.6413. PMID 9144407. 
  3. ^ a b "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)". 
  4. ^ Imai T (Jun 2006). "Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design". Drug Metabolism and Pharmacokinetics 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120. 

Further reading[edit]