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Centrin, EF-hand protein, 1
Protein CETN1 PDB 1m39.png
PDB rendering based on 1m39.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CETN1 ; CEN1; CETN
External IDs OMIM603187 MGI1347086 HomoloGene105668 GeneCards: CETN1 Gene
RNA expression pattern
PBB GE CETN1 207209 at tn.png
More reference expression data
Species Human Mouse
Entrez 1068 26369
Ensembl ENSG00000177143 ENSMUSG00000050996
UniProt Q12798 P41209
RefSeq (mRNA) NM_004066 NM_007593
RefSeq (protein) NP_004057 NP_031619
Location (UCSC) Chr 18:
0.58 – 0.58 Mb
Chr 18:
9.62 – 9.62 Mb
PubMed search [1] [2]

Centrin-1 is a protein that in humans is encoded by the CETN1 gene.[1][2] It belongs to the centrin family of proteins.

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.[2]


  1. ^ Errabolu R, Sanders MA, Salisbury JL (Jun 1994). "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles". J Cell Sci. 107. ( Pt 1): 9–16. PMID 8175926. 
  2. ^ a b "Entrez Gene: CETN1 centrin, EF-hand protein, 1". 

Further reading[edit]