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Centrin, EF-hand protein, 2
Protein CETN2 PDB 1m39.png
PDB rendering based on 1m39.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CETN2 ; CALT; CEN2
External IDs OMIM300006 MGI1347085 HomoloGene55798 GeneCards: CETN2 Gene
RNA expression pattern
PBB GE CETN2 209194 at tn.png
More reference expression data
Species Human Mouse
Entrez 1069 26370
Ensembl ENSG00000147400 ENSMUSG00000031347
UniProt P41208 Q9R1K9
RefSeq (mRNA) NM_004344 NM_019405
RefSeq (protein) NP_004335 NP_062278
Location (UCSC) Chr HG1497_PATCH:
152 – 152 Mb
Chr X:
72.91 – 72.92 Mb
PubMed search [1] [2]

Centrin-2 is a protein that in humans is encoded by the CETN2 gene.[1][2][3] It belongs to the centrin family of proteins.

Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.[3]


CETN2 has been shown to interact with XPC[4] and SFI1.[5]


  1. ^ Tanaka T, Okui K, Nakamura Y (May 1995). "Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization". Genomics 24 (3): 609–10. PMID 7713520. 
  2. ^ Chatterjee A, Tanaka T, Parrish JE, Herman GE (Apr 1996). "Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions". Mamm Genome 6 (11): 802–4. doi:10.1007/BF00539008. PMID 8597638. 
  3. ^ a b "Entrez Gene: CETN2 centrin, EF-hand protein, 2". 
  4. ^ Araki, M; Masutani C; Takemura M; Uchida A; Sugasawa K; Kondoh J; Ohkuma Y; Hanaoka F (Jun 2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair". J. Biol. Chem. (United States) 276 (22): 18665–72. doi:10.1074/jbc.M100855200. ISSN 0021-9258. PMID 11279143. 
  5. ^ Martinez-Sanz, J; Kateb, F; Assairi, L; Blouquit, Y; Bodenhausen, G; Abergel, D; Mouawad, L; Craescu, CT (Jan 8, 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex.". Journal of Molecular Biology 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500. 

Further reading[edit]