CETN2

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Centrin, EF-hand protein, 2
Protein CETN2 PDB 1m39.png
PDB rendering based on 1m39.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CETN2 ; CALT; CEN2
External IDs OMIM300006 MGI1347085 HomoloGene55798 GeneCards: CETN2 Gene
RNA expression pattern
PBB GE CETN2 209194 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1069 26370
Ensembl ENSG00000147400 ENSMUSG00000031347
UniProt P41208 Q9R1K9
RefSeq (mRNA) NM_004344 NM_019405
RefSeq (protein) NP_004335 NP_062278
Location (UCSC) Chr HG1497_PATCH:
152 – 152 Mb
Chr X:
72.91 – 72.92 Mb
PubMed search [1] [2]

Centrin-2 is a protein that in humans is encoded by the CETN2 gene.[1][2][3] It belongs to the centrin family of proteins.

Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.[3]

Interactions[edit]

CETN2 has been shown to interact with XPC[4] and SFI1.[5]

References[edit]

  1. ^ Tanaka T, Okui K, Nakamura Y (May 1995). "Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization". Genomics 24 (3): 609–10. PMID 7713520. 
  2. ^ Chatterjee A, Tanaka T, Parrish JE, Herman GE (Apr 1996). "Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions". Mamm Genome 6 (11): 802–4. doi:10.1007/BF00539008. PMID 8597638. 
  3. ^ a b "Entrez Gene: CETN2 centrin, EF-hand protein, 2". 
  4. ^ Araki, M; Masutani C; Takemura M; Uchida A; Sugasawa K; Kondoh J; Ohkuma Y; Hanaoka F (Jun 2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair". J. Biol. Chem. (United States) 276 (22): 18665–72. doi:10.1074/jbc.M100855200. ISSN 0021-9258. PMID 11279143. 
  5. ^ Martinez-Sanz, J; Kateb, F; Assairi, L; Blouquit, Y; Bodenhausen, G; Abergel, D; Mouawad, L; Craescu, CT (Jan 8, 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex.". Journal of Molecular Biology 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500. 

Further reading[edit]