CGS-21680

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CGS-21680
CGS21680.png
Identifiers
CAS number 120225-54-9
PubChem 3086599
ChemSpider 2343185
ChEBI CHEBI:73283 YesY
ChEMBL CHEMBL331372 YesY
IUPHAR ligand 375
Jmol-3D images Image 1
Properties
Molecular formula C23H29N7O6
Molar mass 499.52
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

CGS-21680 is a specific adenosine A2A subtype receptor agonist. It is usually presented as an organic hydrochloride salt with a molecular weight of 536.0 g/M. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.

The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.


See also[edit]

References[edit]

  • Mayer CA, Haxhiu MA, Martin RJ, Wilson CG (2006). "Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats". J Appl Physiol 100 (1): 91–97. doi:10.1152/japplphysiol.00459.2005. PMID 16141383. 
  • Xie S, Shafer G, Wilson CG, Martin HB (2006). "In vitro adenosine detection with a diamond-based sensor". Dia Rel Mater 15 (2-3): 225–228. doi:10.1016/j.diamond.2005.08.018.