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Chromatin assembly factor 1, subunit A (p150)
Symbols CHAF1A ; CAF-1; CAF1; CAF1B; CAF1P150; P150
External IDs OMIM601246 MGI1351331 HomoloGene4003 GeneCards: CHAF1A Gene
RNA expression pattern
PBB GE CHAF1A 203975 s at tn.png
PBB GE CHAF1A 203976 s at tn.png
PBB GE CHAF1A 214426 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10036 27221
Ensembl ENSG00000167670 ENSMUSG00000002835
UniProt Q13111 Q9QWF0
RefSeq (mRNA) NM_005483 NM_013733
RefSeq (protein) NP_005474 NP_038761
Location (UCSC) Chr 19:
4.4 – 4.45 Mb
Chr 17:
56.04 – 56.07 Mb
PubMed search [1] [2]

Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the CHAF1A gene.[1][2]


Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone tetramers onto replicating DNA in vitro (Kaufman et al., 1995).[supplied by OMIM][2]


CHAF1A has been shown to interact with:


  1. ^ Kaufman PD, Kobayashi R, Kessler N, Stillman B (August 1995). "The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication". Cell 81 (7): 1105–14. doi:10.1016/S0092-8674(05)80015-7. PMID 7600578. 
  2. ^ a b "Entrez Gene: CHAF1A chromatin assembly factor 1, subunit A (p150)". 
  3. ^ a b Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (April 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Rep. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662. 
  4. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ Jiao R, Bachrati CZ, Pedrazzi G, Kuster P, Petkovic M, Li JL et al. (June 2004). "Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1". Mol. Cell. Biol. 24 (11): 4710–9. doi:10.1128/MCB.24.11.4710-4719.2004. PMC 416397. PMID 15143166. 
  6. ^ a b Reese BE, Bachman KE, Baylin SB, Rountree MR (May 2003). "The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1". Mol. Cell. Biol. 23 (9): 3226–36. doi:10.1128/mcb.23.9.3226-3236.2003. PMC 153189. PMID 12697822. 
  7. ^ Lechner MS, Begg GE, Speicher DW, Rauscher FJ (September 2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential". Mol. Cell. Biol. 20 (17): 6449–65. doi:10.1128/mcb.20.17.6449-6465.2000. PMC 86120. PMID 10938122. 

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