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Chromatin assembly factor 1, subunit A (p150)
Symbols CHAF1A ; CAF-1; CAF1; CAF1B; CAF1P150; P150
External IDs OMIM601246 MGI1351331 HomoloGene4003 GeneCards: CHAF1A Gene
RNA expression pattern
PBB GE CHAF1A 203975 s at tn.png
PBB GE CHAF1A 203976 s at tn.png
PBB GE CHAF1A 214426 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10036 27221
Ensembl ENSG00000167670 ENSMUSG00000002835
UniProt Q13111 Q9QWF0
RefSeq (mRNA) NM_005483 NM_013733
RefSeq (protein) NP_005474 NP_038761
Location (UCSC) Chr 19:
4.4 – 4.45 Mb
Chr 17:
56.04 – 56.07 Mb
PubMed search [1] [2]

Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the CHAF1A gene.[1][2]

Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone tetramers onto replicating DNA in vitro (Kaufman et al., 1995).[supplied by OMIM][2]


CHAF1A has been shown to interact with ASF1B,[3][4] ASF1A,[4] MBD1,[5] Bloom syndrome protein[6] and CBX5.[5][7]


  1. ^ Kaufman PD, Kobayashi R, Kessler N, Stillman B (August 1995). "The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication". Cell 81 (7): 1105–14. doi:10.1016/S0092-8674(05)80015-7. PMID 7600578. 
  2. ^ a b "Entrez Gene: CHAF1A chromatin assembly factor 1, subunit A (p150)". 
  3. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  4. ^ a b Mello, Jill A; Silljé Herman H W; Roche Daniele M J; Kirschner Doris B; Nigg Erich A; Almouzni Geneviève (April 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Rep. (England) 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. ISSN 1469-221X. PMC 1084056. PMID 11897662. 
  5. ^ a b Reese, Brian E; Bachman Kurtis E; Baylin Stephen B; Rountree Michael R (May 2003). "The Methyl-CpG Binding Protein MBD1 Interacts with the p150 Subunit of Chromatin Assembly Factor 1". Mol. Cell. Biol. (United States) 23 (9): 3226–36. doi:10.1128/MCB.23.9.3226-3236.2003. ISSN 0270-7306. PMC 153189. PMID 12697822. 
  6. ^ Jiao, Renjie; Bachrati Csanád Z; Pedrazzi Graziella; Kuster Patrick; Petkovic Maja; Li Ji-Liang; Egli Dieter; Hickson Ian D; Stagljar Igor (June 2004). "Physical and Functional Interaction between the Bloom's Syndrome Gene Product and the Largest Subunit of Chromatin Assembly Factor 1". Mol. Cell. Biol. (United States) 24 (11): 4710–9. doi:10.1128/MCB.24.11.4710-4719.2004. ISSN 0270-7306. PMC 416397. PMID 15143166. 
  7. ^ Lechner, M S; Begg G E; Speicher D W; Rauscher F J (September 2000). "Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449–65. doi:10.1128/MCB.20.17.6449-6465.2000. ISSN 0270-7306. PMC 86120. PMID 10938122. 

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