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Chromodomain helicase DNA binding protein 1
Protein CHD1 PDB 2b2t.png
PDB rendering based on 2b2t.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CHD1 ; DKFZp686E2337
External IDs OMIM602118 MGI88393 HomoloGene68174 GeneCards: CHD1 Gene
EC number
RNA expression pattern
PBB GE CHD1 204258 at tn.png
More reference expression data
Species Human Mouse
Entrez 1105 12648
Ensembl ENSG00000153922 ENSMUSG00000023852
UniProt O14646 P40201
RefSeq (mRNA) NM_001270 NM_007690
RefSeq (protein) NP_001261 NP_031716
Location (UCSC) Chr 5:
98.19 – 98.26 Mb
Chr 17:
15.7 – 15.77 Mb
PubMed search [1] [2]

Chromodomain-helicase-DNA-binding protein 1 is an enzyme that in humans is encoded by the CHD1 gene.[1][2][3]

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.[3]


CHD1 has been shown to interact with Nuclear receptor co-repressor 1.[4]


  1. ^ Delmas V, Stokes DG, Perry RP (Apr 1993). "A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain". Proc Natl Acad Sci U S A 90 (6): 2414–8. doi:10.1073/pnas.90.6.2414. PMC 46097. PMID 8460153. 
  2. ^ Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS (Nov 1997). "Characterization of the CHD family of proteins". Proc Natl Acad Sci U S A 94 (21): 11472–7. doi:10.1073/pnas.94.21.11472. PMC 23509. PMID 9326634. 
  3. ^ a b "Entrez Gene: CHD1 chromodomain helicase DNA binding protein 1". 
  4. ^ Tai, Helen H; Geisterfer Margit; Bell John C; Moniwa Mariko; Davie James R; Boucher Lorrie; McBurney Michael W (Aug 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. (United States) 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. ISSN 0006-291X. PMID 12890497. 

Further reading[edit]