CHFR

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Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
Protein CHFR PDB 1lgp.png
PDB rendering based on 1lgp.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CHFR ; RNF116; RNF196
External IDs OMIM605209 MGI2444898 HomoloGene10078 GeneCards: CHFR Gene
RNA expression pattern
PBB GE CHFR 218803 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55743 231600
Ensembl ENSG00000072609 ENSMUSG00000014668
UniProt Q96EP1 Q810L3
RefSeq (mRNA) NM_001161344 NM_172717
RefSeq (protein) NP_001154816 NP_766305
Location (UCSC) Chr 12:
133.42 – 133.49 Mb
Chr 5:
110.14 – 110.17 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.[1][2][3]


References[edit]

  1. ^ Scolnick DM, Halazonetis TD (Aug 2000). "Chfr defines a mitotic stress checkpoint that delays entry into metaphase". Nature 406 (6794): 430–5. doi:10.1038/35019108. PMID 10935642. 
  2. ^ Kang D, Chen J, Wong J, Fang G (Jan 2002). "The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition". J Cell Biol 156 (2): 249–59. doi:10.1083/jcb.200108016. PMC 2199220. PMID 11807090. 
  3. ^ "Entrez Gene: CHFR checkpoint with forkhead and ring finger domains". 

Further reading[edit]