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Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
Protein CHFR PDB 1lgp.png
PDB rendering based on 1lgp.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CHFR ; RNF116; RNF196
External IDs OMIM605209 MGI2444898 HomoloGene10078 GeneCards: CHFR Gene
RNA expression pattern
PBB GE CHFR 218803 at tn.png
More reference expression data
Species Human Mouse
Entrez 55743 231600
Ensembl ENSG00000072609 ENSMUSG00000014668
UniProt Q96EP1 Q810L3
RefSeq (mRNA) NM_001161344 NM_172717
RefSeq (protein) NP_001154816 NP_766305
Location (UCSC) Chr 12:
133.42 – 133.49 Mb
Chr 5:
110.14 – 110.17 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.[1][2][3]


  1. ^ Scolnick DM, Halazonetis TD (Aug 2000). "Chfr defines a mitotic stress checkpoint that delays entry into metaphase". Nature 406 (6794): 430–5. doi:10.1038/35019108. PMID 10935642. 
  2. ^ Kang D, Chen J, Wong J, Fang G (Jan 2002). "The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition". J Cell Biol 156 (2): 249–59. doi:10.1083/jcb.200108016. PMC 2199220. PMID 11807090. 
  3. ^ "Entrez Gene: CHFR checkpoint with forkhead and ring finger domains". 

Further reading[edit]