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Choline kinase alpha
Protein CHKA PDB 2cko.png
PDB rendering based on 2cko.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CHKA ; CHK; CK; CKI; EK
External IDs OMIM118491 MGI107760 HomoloGene88575 ChEMBL: 3117 GeneCards: CHKA Gene
EC number,
RNA expression pattern
PBB GE CHKA 204233 s at tn.png
PBB GE CHKA 204266 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1119 12660
Ensembl ENSG00000110721 ENSMUSG00000024843
UniProt P35790 O54804
RefSeq (mRNA) NM_001277 NM_001025566
RefSeq (protein) NP_001268 NP_001258425
Location (UCSC) Chr 11:
67.82 – 67.89 Mb
Chr 19:
3.85 – 3.89 Mb
PubMed search [1] [2]

Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene.[1][2][3]

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.[3]

In melanocytic cells CHKA gene expression may be regulated by MITF.[4]


  1. ^ Hosaka K, Tanaka S, Nikawa J, Yamashita S (Aug 1992). "Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation". FEBS Lett 304 (2–3): 229–32. doi:10.1016/0014-5793(92)80625-Q. PMID 1618328. 
  2. ^ Aoyama C, Liao H, Ishidate K (Mar 2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog Lipid Res 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397. 
  3. ^ a b "Entrez Gene: CHKA choline kinase alpha". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

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