Choline kinase beta is a protein encoded by the CHKBgene. This gene is found on chromosome 22 in humans.
Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.
^Yamazaki N, Yamanaka Y, Hashimoto Y, Shinohara Y, Shima A, Terada H (June 1997). "Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I". FEBS Lett.409 (3): 401–6. doi:10.1016/S0014-5793(97)00561-9. PMID9224698.
Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res.8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID11258795.
Yamazaki N, Shinohara Y, Kajimoto K, et al. (2000). "Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I". J. Biol. Chem.275 (41): 31739–46. doi:10.1074/jbc.M006322200. PMID10918069.
Aoyama C, Yamazaki N, Terada H, Ishidate K (2000). "Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta". J. Lipid Res.41 (3): 452–64. PMID10706593.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID10493829.
Aoyama C, Nakashima K, Matsui M, Ishidate K (1998). "Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase". Biochim. Biophys. Acta1390 (1): 1–7. doi:10.1016/s0005-2760(97)00177-x. PMID9487136.
Yamazaki N, Yamanaka Y, Hashimoto Y, et al. (1997). "Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I". FEBS Lett.409 (3): 401–6. doi:10.1016/S0014-5793(97)00561-9. PMID9224698.