CHKB (gene)

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Choline kinase beta
Protein CHKB PDB 2ig7.png
PDB rendering based on 2ig7.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM612395 MGI1328313 HomoloGene88718 GeneCards: CHKB Gene
EC number,
RNA expression pattern
PBB GE CHKB 204193 at tn.png
More reference expression data
Species Human Mouse
Entrez 1120 12651
Ensembl ENSG00000100288 ENSMUSG00000022617
UniProt Q9Y259 O55229
RefSeq (mRNA) NM_005198 NM_007692
RefSeq (protein) NP_005189 NP_031718
Location (UCSC) Chr 22:
51.02 – 51.04 Mb
Chr 15:
89.42 – 89.43 Mb
PubMed search [1] [2]

Choline kinase beta is a protein encoded by the CHKB gene.[1][2] This gene is found on chromosome 22 in humans.[3]

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.[3]


  1. ^ Yamazaki N, Yamanaka Y, Hashimoto Y, Shinohara Y, Shima A, Terada H (June 1997). "Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I". FEBS Lett. 409 (3): 401–6. doi:10.1016/S0014-5793(97)00561-9. PMID 9224698. 
  2. ^ Aoyama C, Liao H, Ishidate K (May 2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog. Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397. 
  3. ^ a b "Entrez Gene: CHKB choline kinase beta". 

Further reading[edit]