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Cell adhesion molecule with homology to L1CAM (close homolog of L1)
Symbols CHL1 ; CALL; L1CAM2
External IDs OMIM607416 MGI1098266 HomoloGene21314 GeneCards: CHL1 Gene
Species Human Mouse
Entrez 10752 12661
Ensembl ENSG00000134121 ENSMUSG00000030077
UniProt O00533 P70232
RefSeq (mRNA) NM_001253387 NM_007697
RefSeq (protein) NP_001240316 NP_031723
Location (UCSC) Chr 3:
0.24 – 0.45 Mb
Chr 6:
103.51 – 103.73 Mb
PubMed search [1] [2]

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene.[1]

CHL1 is a cell adhesion molecule closely related to the L1. In melanocytic cells CHL1 gene expression may be regulated by MITF,[2] and can act as a helicase protein during the interphase stage of mitosis.

The protein however has dynamic localisation, meaning that it has not only multiple roles in the cell, but also various locations.


  1. ^ Wei MH, Karavanova I, Ivanov SV, Popescu NC, Keck CL, Pack S, Eisen JA, Lerman MI (September 1998). "In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules". Hum. Genet. 103 (3): 355–64. doi:10.1007/s004390050829. PMID 9799093. 
  2. ^ Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

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