CHP (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Calcineurin-like EF-hand protein 1
Protein CHP PDB 2ct9.png
PDB rendering based on 2ct9.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CHP1 ; CHP; SLC9A1BP; Sid470p; p22; p24
External IDs OMIM606988 MGI1927185 HomoloGene5235 GeneCards: CHP1 Gene
RNA expression pattern
PBB GE CHP 214665 s at tn.png
PBB GE CHP 207993 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11261 56398
Ensembl ENSG00000187446 ENSMUSG00000014077
UniProt Q99653 P61022
RefSeq (mRNA) NM_007236 NM_019769
RefSeq (protein) NP_009167 NP_062743
Location (UCSC) Chr 15:
41.52 – 41.57 Mb
Chr 2:
119.55 – 119.59 Mb
PubMed search [1] [2]

Calcium binding protein P22, also known as CHP, is a human gene.[1]

The protein encoded by this gene is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.[1]


CHP (gene) has been shown to interact with Sodium-hydrogen antiporter 1[2][3][4] and Sodium-hydrogen antiporter 3.[2]


  1. ^ a b "Entrez Gene: CHP calcium binding protein P22". 
  2. ^ a b Inoue, Hiroki; Nakamura Yutaka; Nagita Mana; Takai Tomoyo; Masuda Miho; Nakamura Norihiro; Kanazawa Hiroshi (Feb 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. (Japan) 26 (2): 148–55. doi:10.1248/bpb.26.148. ISSN 0918-6158. PMID 12576672. 
  3. ^ Lin, X; Barber D L (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. ISSN 0027-8424. PMC 38044. PMID 8901634. 
  4. ^ Pang, T; Su X; Wakabayashi S; Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. (United States) 276 (20): 17367–72. doi:10.1074/jbc.M100296200. ISSN 0021-9258. PMID 11350981. 

Further reading[edit]