CHRNA10

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Cholinergic receptor, nicotinic, alpha 10 (neuronal)
Identifiers
Symbol CHRNA10
External IDs OMIM606372 MGI3609260 HomoloGene56886 IUPHAR: α10 ChEMBL: 2551 GeneCards: CHRNA10 Gene
Orthologs
Species Human Mouse
Entrez 57053 504186
Ensembl ENSG00000129749 ENSMUSG00000066279
UniProt Q9GZZ6 B2RX82
RefSeq (mRNA) NM_020402 NM_001081424
RefSeq (protein) NP_065135 NP_001074893
Location (UCSC) Chr 11:
3.69 – 3.69 Mb
Chr 7:
102.11 – 102.12 Mb
PubMed search [1] [2]

Neuronal acetylcholine receptor subunit alpha-10 also known as cholinergic receptor nicotinic alpha 10 is a protein that in humans is encoded by the CHRNA10 gene.[1] The protein encoded by this gene is a subunit of the nicotinic acetylcholine receptor (nAchR).

This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.[2] Furthermore selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[3]

References[edit]

  1. ^ Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA (May 2001). "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)". Genomics 73 (3): 272–83. doi:10.1006/geno.2000.6503. PMID 11350119. 
  2. ^ Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J (December 2007). "The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20594–9. doi:10.1073/pnas.0708545105. PMC 2154476. PMID 18077337. 
  3. ^ Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. doi:10.1073/pnas.0608715103. PMC 1635975. PMID 17101979. 

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