CHRNA2

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Cholinergic receptor, nicotinic, alpha 2 (neuronal)
Identifiers
Symbol CHRNA2
External IDs OMIM118502 MGI87886 HomoloGene20193 IUPHAR: α2 ChEMBL: 1794 GeneCards: CHRNA2 Gene
RNA expression pattern
PBB GE CHRNA2 207868 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1135 110902
Ensembl ENSG00000120903 ENSMUSG00000022041
UniProt Q15822 Q91X60
RefSeq (mRNA) NM_000742 NM_144803
RefSeq (protein) NP_000733 NP_659052
Location (UCSC) Chr 8:
27.32 – 27.34 Mb
Chr 14:
66.14 – 66.15 Mb
PubMed search [1] [2]

Neuronal acetylcholine receptor subunit alpha-2 also known as nAChRα2 is a protein that in humans is encoded by the CHRNA2 gene.[1][2]

Function[edit]

Knockout of this gene in mice potentiates nicotine-modulated behaviors.[3]

See also[edit]

References[edit]

  1. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988. 
  2. ^ "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)". 
  3. ^ Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (May 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi:10.1523/JNEUROSCI.4731-12.2013. PMID 23637165. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.