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Cholinergic receptor, nicotinic, alpha 2 (neuronal)
Symbol CHRNA2
External IDs OMIM118502 MGI87886 HomoloGene20193 IUPHAR: 463 ChEMBL: 1794 GeneCards: CHRNA2 Gene
RNA expression pattern
PBB GE CHRNA2 207868 at tn.png
More reference expression data
Species Human Mouse
Entrez 1135 110902
Ensembl ENSG00000120903 ENSMUSG00000022041
UniProt Q15822 Q91X60
RefSeq (mRNA) NM_000742 NM_144803
RefSeq (protein) NP_000733 NP_659052
Location (UCSC) Chr 8:
27.32 – 27.34 Mb
Chr 14:
66.14 – 66.15 Mb
PubMed search [1] [2]

Neuronal acetylcholine receptor subunit alpha-2 also known as nAChRα2 is a protein that in humans is encoded by the CHRNA2 gene.[1][2]


Knockout of this gene in mice potentiates nicotine-modulated behaviors.[3]

See also[edit]


  1. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988. 
  2. ^ "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)". 
  3. ^ Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (May 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi:10.1523/JNEUROSCI.4731-12.2013. PMID 23637165. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.