CHRNA6

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Cholinergic receptor, nicotinic, alpha 6 (neuronal)
Identifiers
Symbols CHRNA6 ; CHNRA6
External IDs OMIM606888 MGI106213 HomoloGene20888 IUPHAR: α6 ChEMBL: 2356 GeneCards: CHRNA6 Gene
RNA expression pattern
PBB GE CHRNA6 207568 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8973 11440
Ensembl ENSG00000147434 ENSMUSG00000031491
UniProt Q15825 Q9R0W9
RefSeq (mRNA) NM_001199279 NM_021369
RefSeq (protein) NP_001186208 NP_067344
Location (UCSC) Chr 8:
42.61 – 42.65 Mb
Chr 8:
27.4 – 27.41 Mb
PubMed search [1] [2]

Cholinergic receptor, nicotinic, alpha 6, also known as CHRNA6, is a human gene,[1] which codes for the α6 subunit found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine-releasing neurons in the midbrain,[2] and dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine.[3][4][5] Due to their selective localisation on dopaminergic neurons, α6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease.[6][7]


Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
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Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". 

See also[edit]

References[edit]

  1. ^ "Entrez Gene: CHRNA6 cholinergic receptor, nicotinic, alpha 6". 
  2. ^ Meyer, EL, Yoshikami, D, McIntosh, JM (2008). "The Neuronal Nicotinic Acetylcholine Receptors α4* and α6* Differentially Modulate Dopamine Release in Mouse Striatal Slices". Journal of Neurochemistry 105 (5): 1761–9. doi:10.1111/j.1471-4159.2008.05266.x. PMC 2527994. PMID 18248619. 
  3. ^ Calabresi, P, Massimiliano, DF. (Oct 2008). "ACh/Dopamine Crosstalk in Motor Control and Reward: A Crucial Role for α6-Containing Nicotinic Receptors?". Neuron 60 (1): 4–7. doi:10.1016/j.neuron.2008.09.031. PMID 18940582. 
  4. ^ Drenan, RM; Grady, SR; Whiteaker, P; McClure-Begley, T; McKinney, S; Miwa, JM; Bupp, S; Heintz, N et al. (Oct 2008). "In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity α6* Nicotinic Acetylcholine Receptors". Neuron 60 (1): 123–136. doi:10.1016/j.neuron.2008.09.009. PMC 2632732. PMID 18940593. 
  5. ^ Exley, R, Clements, MA, Hartung, H, McIntosh, JM, Cragg, SJ (2008). "Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens". Neuropsychopharmacology 33 (9): 2158–66. doi:10.1038/sj.npp.1301617. PMID 18033235. 
  6. ^ Quik, M, McIntosh, JM (2006). "Striatal alpha6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapy". The Journal of Pharmacology and Experimental Therapeutics 316 (2): 481–9. doi:10.1124/jpet.105.094375. PMID 16210393. 
  7. ^ Bordia, T, Grady, SR, McIntosh, JM, Quik, M (2007). "Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum". Molecular Pharmacology 72 (1): 52–61. doi:10.1124/mol.107.035998. PMID 17409284. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.