CHRNA9

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Cholinergic receptor, nicotinic, alpha 9 (neuronal)
Identifiers
Symbols CHRNA9 ; HSA243342; NACHRA9
External IDs OMIM605116 MGI1202403 HomoloGene9729 IUPHAR: α9 ChEMBL: 2184 GeneCards: CHRNA9 Gene
RNA expression pattern
PBB GE CHRNA9 221107 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55584 231252
Ensembl ENSG00000174343 ENSMUSG00000029205
UniProt Q9UGM1 G3X8Z7
RefSeq (mRNA) NM_017581 NM_001081104
RefSeq (protein) NP_060051 NP_001074573
Location (UCSC) Chr 4:
40.34 – 40.36 Mb
Chr 5:
65.93 – 65.98 Mb
PubMed search [1] [2]

Neuronal acetylcholine receptor subunit alpha-9 is a protein that in humans is encoded by the CHRNA9 gene.[1]

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.[1]

Selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[2]

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References[edit]

  1. ^ a b "Entrez Gene: CHRNA9 cholinergic receptor, nicotinic, alpha 9". 
  2. ^ Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. doi:10.1073/pnas.0608715103. PMC 1635975. PMID 17101979. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.