CHRNB1

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Cholinergic receptor, nicotinic, beta 1 (muscle)
Identifiers
Symbols CHRNB1 ; ACHRB; CHRNB; CMS1D; CMS2A; SCCMS
External IDs OMIM100710 MGI87890 HomoloGene594 IUPHAR: β1 ChEMBL: 3355 GeneCards: CHRNB1 Gene
RNA expression pattern
PBB GE CHRNB1 206703 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1140 11443
Ensembl ENSG00000170175 ENSMUSG00000041189
UniProt P11230 P09690
RefSeq (mRNA) NM_000747 NM_009601
RefSeq (protein) NP_000738 NP_033731
Location (UCSC) Chr 17:
7.45 – 7.46 Mb
Chr 11:
69.78 – 69.8 Mb
PubMed search [1] [2]

Acetylcholine receptor subunit beta is a protein that in humans is encoded by the CHRNB1 gene.[1]

The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.