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CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
Symbols CHTF18 ; C16orf41; C321D2.2; C321D2.3; C321D2.4; CHL12; Ctf18; RUVBL
External IDs OMIM613201 MGI2384887 HomoloGene32532 GeneCards: CHTF18 Gene
Species Human Mouse
Entrez 63922 214901
Ensembl ENSG00000127586 ENSMUSG00000019214
UniProt Q8WVB6 Q8BIW9
RefSeq (mRNA) NM_022092 NM_145409
RefSeq (protein) NP_071375 NP_663384
Location (UCSC) Chr 16:
0.84 – 0.85 Mb
Chr 17:
25.72 – 25.73 Mb
PubMed search [1] [2]

Chromosome transmission fidelity protein 18 homolog is a protein that in humans is encoded by the CHTF18 gene.[1][2]


CHTF18 has been shown to interact with DCC1,[3][4] RFC2,[3][4] RFC3,[3][4] PCNA,[1] RFC4[3] and RFC5.[3]


  1. ^ a b Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J Biol Chem 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929. 
  2. ^ "Entrez Gene: CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)". 
  3. ^ a b c d e Bermudez, Vladimir P; Maniwa Yoshimasa; Tappin Inger; Ozato Keiko; Yokomori Kyoko; Hurwitz Jerard (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (18): 10237–42. doi:10.1073/pnas.1434308100. ISSN 0027-8424. PMC 193545. PMID 12930902. 
  4. ^ a b c Merkle, Carolin J; Karnitz Larry M, Henry-Sánchez John T, Chen Junjie (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". J. Biol. Chem. (United States) 278 (32): 30051–6. doi:10.1074/jbc.M211591200. ISSN 0021-9258. PMID 12766176. 

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