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Calcium and integrin binding 1 (calmyrin)
Protein CIB1 PDB 1dgu.png
PDB rendering based on 1dgu.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CIB1 ; CIB; CIBP; KIP1; PRKDCIP; SIP2-28
External IDs OMIM602293 MGI1344418 HomoloGene4654 GeneCards: CIB1 Gene
RNA expression pattern
PBB GE CIB1 201953 at tn.png
More reference expression data
Species Human Mouse
Entrez 10519 23991
Ensembl ENSG00000185043 ENSMUSG00000030538
UniProt Q99828 Q9Z0F4
RefSeq (mRNA) NM_001277764 NM_001291275
RefSeq (protein) NP_001264693 NP_001278204
Location (UCSC) Chr 15:
90.77 – 90.78 Mb
Chr 7:
80.23 – 80.23 Mb
PubMed search [1] [2]

Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene.[1][2][3]

The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end-joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).[3]


CIB1 has been shown to interact with RAC3,[4] PSEN2,[5] DNA-PKcs,[6] UBR5[7] and CD61.[1]


  1. ^ a b Naik UP, Patel PM, Parise LV (Apr 1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". J Biol Chem 272 (8): 4651–4. doi:10.1074/jbc.272.8.4651. PMID 9030514. 
  2. ^ Hattori A, Seki N, Hayashi A, Kozuma S, Saito T (Aug 2000). "Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP)". DNA Seq 10 (6): 415–8. doi:10.3109/10425170009015612. PMID 10826701. 
  3. ^ a b "Entrez Gene: CIB1 calcium and integrin binding 1 (calmyrin)". 
  4. ^ Haataja, Leena; Kaartinen Vesa; Groffen John; Heisterkamp Nora (Mar 2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. (United States) 277 (10): 8321–8. doi:10.1074/jbc.M105363200. ISSN 0021-9258. PMID 11756406. 
  5. ^ Stabler, S M; Ostrowski L L; Janicki S M; Monteiro M J (Jun 1999). "A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein". J. Cell Biol. (UNITED STATES) 145 (6): 1277–92. doi:10.1083/jcb.145.6.1277. ISSN 0021-9525. PMC 2133148. PMID 10366599. 
  6. ^ Wu, X; Lieber M R (Oct 1997). "Interaction between DNA-dependent protein kinase and a novel protein, KIP". Mutat. Res. (NETHERLANDS) 385 (1): 13–20. doi:10.1016/s0921-8777(97)00035-9. ISSN 0027-5107. PMID 9372844. 
  7. ^ Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A; Sutherland Robert L; Watts Colin K W (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. (United States) 277 (29): 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095. 

Further reading[edit]