CIB1

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Calcium and integrin binding 1 (calmyrin)
Protein CIB1 PDB 1dgu.png
PDB rendering based on 1dgu.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CIB1 ; CIB; CIBP; KIP1; PRKDCIP; SIP2-28
External IDs OMIM602293 MGI1344418 HomoloGene4654 GeneCards: CIB1 Gene
RNA expression pattern
PBB GE CIB1 201953 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10519 23991
Ensembl ENSG00000185043 ENSMUSG00000030538
UniProt Q99828 Q9Z0F4
RefSeq (mRNA) NM_001277764 NM_001291275
RefSeq (protein) NP_001264693 NP_001278204
Location (UCSC) Chr 15:
90.77 – 90.78 Mb
Chr 7:
80.23 – 80.23 Mb
PubMed search [1] [2]

Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene.[1][2][3]

The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end-joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).[3]

Interactions[edit]

CIB1 has been shown to interact with RAC3,[4] PSEN2,[5] DNA-PKcs,[6] UBR5[7] and CD61.[1]

References[edit]

  1. ^ a b Naik UP, Patel PM, Parise LV (Apr 1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". J Biol Chem 272 (8): 4651–4. doi:10.1074/jbc.272.8.4651. PMID 9030514. 
  2. ^ Hattori A, Seki N, Hayashi A, Kozuma S, Saito T (Aug 2000). "Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP)". DNA Seq 10 (6): 415–8. doi:10.3109/10425170009015612. PMID 10826701. 
  3. ^ a b "Entrez Gene: CIB1 calcium and integrin binding 1 (calmyrin)". 
  4. ^ Haataja, Leena; Kaartinen Vesa; Groffen John; Heisterkamp Nora (Mar 2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. (United States) 277 (10): 8321–8. doi:10.1074/jbc.M105363200. ISSN 0021-9258. PMID 11756406. 
  5. ^ Stabler, S M; Ostrowski L L; Janicki S M; Monteiro M J (Jun 1999). "A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein". J. Cell Biol. (UNITED STATES) 145 (6): 1277–92. doi:10.1083/jcb.145.6.1277. ISSN 0021-9525. PMC 2133148. PMID 10366599. 
  6. ^ Wu, X; Lieber M R (Oct 1997). "Interaction between DNA-dependent protein kinase and a novel protein, KIP". Mutat. Res. (NETHERLANDS) 385 (1): 13–20. doi:10.1016/s0921-8777(97)00035-9. ISSN 0027-5107. PMID 9372844. 
  7. ^ Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A; Sutherland Robert L; Watts Colin K W (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. (United States) 277 (29): 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095. 

Further reading[edit]