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Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Symbols CILP ; CILP-1; HsT18872
External IDs OMIM603489 MGI2444507 HomoloGene2679 GeneCards: CILP Gene
RNA expression pattern
PBB GE CILP 206227 at tn.png
More reference expression data
Species Human Mouse
Entrez 8483 214425
Ensembl ENSG00000138615 ENSMUSG00000042254
UniProt O75339 Q66K08
RefSeq (mRNA) NM_003613 NM_173385
RefSeq (protein) NP_003604 NP_775561
Location (UCSC) Chr 15:
65.49 – 65.5 Mb
Chr 9:
65.27 – 65.28 Mb
PubMed search [1] [2]

Cartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene.[1][2][3]

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.[3]


  1. ^ Lorenzo P, Neame P, Sommarin Y, Heinegard D (Oct 1998). "Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase". J Biol Chem 273 (36): 23469–75. doi:10.1074/jbc.273.36.23469. PMID 9722584. 
  2. ^ Lorenzo P, Bayliss MT, Heinegard D (Oct 1998). "A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age". J Biol Chem 273 (36): 23463–8. doi:10.1074/jbc.273.36.23463. PMID 9722583. 
  3. ^ a b "Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase". 

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