CIT (gene)

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Citron rho-interacting serine/threonine kinase
Symbols CIT ; CRIK; STK21
External IDs OMIM605629 MGI105313 HomoloGene21404 ChEMBL: 5579 GeneCards: CIT Gene
EC number
RNA expression pattern
PBB GE CIT 212801 at tn.png
PBB GE CIT gnf1h02793 at tn.png
More reference expression data
Species Human Mouse
Entrez 11113 12704
Ensembl ENSG00000122966 ENSMUSG00000029516
UniProt O14578 P49025
RefSeq (mRNA) NM_001206999 NM_007708
RefSeq (protein) NP_001193928 NP_031734
Location (UCSC) Chr 12:
120.12 – 120.32 Mb
Chr 5:
115.85 – 116.01 Mb
PubMed search [1] [2]

Citron Rho-interacting kinase is an enzyme that in humans is encoded by the CIT gene.[1][2]


CIT (gene) has been shown to interact with RHOB[3] and RHOA.[3][4]


  1. ^ Di Cunto F, Calautti E, Hsiao J, Ong L, Topley G, Turco E, Dotto GP (Dec 1998). "Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron". J Biol Chem 273 (45): 29706–11. doi:10.1074/jbc.273.45.29706. PMID 9792683. 
  2. ^ "Entrez Gene: CIT citron (rho-interacting, serine/threonine kinase 21)". 
  3. ^ a b Madaule, P; Furuyashiki T; Reid T; Ishizaki T; Watanabe G; Morii N; Narumiya S (Dec 1995). "A novel partner for the GTP-bound forms of rho and rac". FEBS Lett. (NETHERLANDS) 377 (2): 243–8. doi:10.1016/0014-5793(95)01351-2. ISSN 0014-5793. PMID 8543060. 
  4. ^ Riento, Kirsi; Guasch Rosa M; Garg Ritu; Jin Boquan; Ridley Anne J (Jun 2003). "RhoE binds to ROCK I and inhibits downstream signaling". Mol. Cell. Biol. (United States) 23 (12): 4219–29. doi:10.1128/MCB.23.12.4219-4229.2003. ISSN 0270-7306. PMC 156133. PMID 12773565. 

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