CLASP1

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Cytoplasmic linker associated protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CLASP1 ; MAST1
External IDs OMIM605852 MGI1923957 HomoloGene41024 GeneCards: CLASP1 Gene
RNA expression pattern
PBB GE CLASP1 212752 at tn.png
PBB GE CLASP1 gnf1h03920 at tn.png
PBB GE CLASP1 gnf1h03925 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23332 76707
Ensembl ENSG00000074054 ENSMUSG00000064302
UniProt Q7Z460 Q80TV8
RefSeq (mRNA) NM_001142273 NM_001081276
RefSeq (protein) NP_001135745 NP_001074745
Location (UCSC) Chr 2:
122.1 – 122.41 Mb
Chr 1:
118.39 – 118.61 Mb
PubMed search [1] [2]

Cytoplasmic linker associated protein 1, also known as CLASP1, is a protein which in humans is encoded by the CLASP1 gene.[1]

Function[edit]

CLASP1 belongs to a family of microtubule-associated proteins involved in attachment of microtubules to the cell cortex in animals[2] and plants.[3] CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle.[1][4]

References[edit]

  1. ^ a b "Entrez Gene: CLASP1 cytoplasmic linker associated protein 1". 
  2. ^ Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Developmental Cell 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950. 
  3. ^ Ambrose JC, Wasteneys GO (2008). "CLASP Modulates Microtubule-Cortex Interaction during Self-Organization of Acentrosomal Microtubules". Molecular Biology of the Cell 19 (11): 4730–4737. doi:10.1091/mbc.E08-06-0665. PMC 2575154. PMID 18716054. 
  4. ^ Maiato H, Fairley EA, Rieder CL, Swedlow JR, Sunkel CE, Earnshaw WC (June 2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. PMID 12837247. 

Further reading[edit]