CLCA3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Chloride channel accessory 3, pseudogene
Identifiers
Symbols CLCA3P ; CLCA3
External IDs OMIM604337 GeneCards: CLCA3P Gene
Orthologs
Species Human Mouse
Entrez 9629 23844
Ensembl ENSG00000153923 ENSMUSG00000028255
UniProt Q9Y6N3 Q9D7Z6
RefSeq (mRNA) NM_004921 NM_017474
RefSeq (protein) n/a NP_059502
Location (UCSC) Chr 1:
87.1 – 87.12 Mb
Chr 3:
144.67 – 144.7 Mb
PubMed search [1] [2]

Chloride channel, calcium activated, family member 3, also known as CLCA3, is a protein which in humans is encoded by the CLCA3P pseudogene. The protein encoded by this gene is a chloride channel.[1] This protein is not expressed in humans but is in certain other species such as mouse.

Function[edit]

This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this gene is unlikely to be protein-coding.[2] Protein structure prediction methods suggest the N-terminal region of CLCA3 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[3]

See also[edit]

References[edit]

  1. ^ Gruber AD, Pauli BU (March 1999). "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl channels". Biochim. Biophys. Acta 1444 (3): 418–23. doi:10.1016/S0167-4781(99)00008-1. PMID 10095065. 
  2. ^ "Entrez Gene: chloride channel accessory 3 (pseudogene)". 
  3. ^ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.