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Claudin 1
External IDs OMIM603718 MGI1276109 HomoloGene9620 GeneCards: CLDN1 Gene
RNA expression pattern
PBB GE CLDN1 218182 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9076 12737
Ensembl ENSG00000163347 ENSMUSG00000022512
UniProt O95832 O88551
RefSeq (mRNA) NM_021101 NM_016674
RefSeq (protein) NP_066924 NP_057883
Location (UCSC) Chr 3:
190.02 – 190.04 Mb
Chr 16:
26.36 – 26.37 Mb
PubMed search [1] [2]

Claudin-1 is a protein that in humans is encoded by the CLDN1 gene.[1][2] It belongs to the group of claudins.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.[3]


CLDN1 has been shown to interact with CLDN5[4] and CLDN3.[4]


  1. ^ Halford S, Spencer P, Greenwood J, Winton H, Hunt DM, Adamson P (Jun 2000). "Assignment of claudin-1 (CLDN1) to human chromosome 3q28→q29 with somatic cell hybrids". Cytogenet Cell Genet 88 (3–4): 217. doi:10.1159/000015553. PMID 10828592. 
  2. ^ Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A 96 (2): 511–6. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664. 
  3. ^ "Entrez Gene: CLDN1 claudin 1". 
  4. ^ a b Coyne, Carolyn B; Gambling Todd M; Boucher Richard C; Carson Johnny L; Johnson Larry G (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. (United States) 285 (5): L1166–78. doi:10.1152/ajplung.00182.2003. ISSN 1040-0605. PMID 12909588. 

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