CLDN2

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Claudin 2
Identifiers
Symbol CLDN2
External IDs OMIM300520 MGI1276110 HomoloGene9621 GeneCards: CLDN2 Gene
Orthologs
Species Human Mouse
Entrez 9075 12738
Ensembl ENSG00000165376 ENSMUSG00000047230
UniProt P57739 O88552
RefSeq (mRNA) NM_001171092 NM_016675
RefSeq (protein) NP_001164563 NP_057884
Location (UCSC) Chr X:
106.14 – 106.17 Mb
Chr X:
139.8 – 139.81 Mb
PubMed search [1] [2]

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene.[1][2] It belongs to the group of claudins.

Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM][2]

Function[edit]

Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule.[3] Mice that are deficient in claudin-2 have reduced reabsorption of Na+ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells.[4]

References[edit]

  1. ^ Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A 96 (2): 511–6. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664. 
  2. ^ a b "Entrez Gene: CLDN2 claudin 2". 
  3. ^ Muto, S.; Hata, M.; Taniguchi, J.; Tsuruoka, S.; Moriwaki, K.; Saitou, M.; Furuse, K.; Sasaki, H.; Fujimura, A.; Imai, M.; Kusano, E.; Tsukita, S.; Furuse, M. (2010). "Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules". Proceedings of the National Academy of Sciences 107 (17): 8011–8016. doi:10.1073/pnas.0912901107. PMC 2867900. PMID 20385797.  edit
  4. ^ Rosenthal, R.; Milatz, S.; Krug, S. M.; Oelrich, B.; Schulzke, J. -D.; Amasheh, S.; Gunzel, D.; Fromm, M. (2010). "Claudin-2, a component of the tight junction, forms a paracellular water channel". Journal of Cell Science 123 (11): 1913–1921. doi:10.1242/jcs.060665. PMID 20460438.  edit

Further reading[edit]