C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12Agene.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
van Rhenen A, van Dongen GA, Kelder A, et al. (2007). "The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells.". Blood110 (7): 2659–66. doi:10.1182/blood-2007-03-083048. PMID17609428.
Marshall AS, Willment JA, Pyz E, et al. (2006). "Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation.". Eur. J. Immunol.36 (8): 2159–69. doi:10.1002/eji.200535628. PMID16838277.
Marshall AS, Willment JA, Lin HH, et al. (2004). "Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes.". J. Biol. Chem.279 (15): 14792–802. doi:10.1074/jbc.M313127200. PMID14739280.
Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.". Proteins53 (1): 44–55. doi:10.1002/prot.10440. PMID12945048.