CLEC12A

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C-type lectin domain family 12, member A
Identifiers
Symbols CLEC12A ; CLL-1; CLL1; DCAL-2; MICL
External IDs OMIM612088 MGI3040968 HomoloGene51378 GeneCards: CLEC12A Gene
Orthologs
Species Human Mouse
Entrez 160364 232413
Ensembl ENSG00000172322 ENSMUSG00000053063
UniProt Q5QGZ9 Q504P2
RefSeq (mRNA) NM_001207010 NM_177686
RefSeq (protein) NP_001193939 NP_808354
Location (UCSC) Chr 12:
10.1 – 10.15 Mb
Chr 6:
129.34 – 129.37 Mb
PubMed search [1] [2]

C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.[1]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.[1]

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