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C-type lectin domain family 1, member A
Symbols CLEC1A ; CLEC-1; CLEC1
External IDs OMIM606782 MGI2444151 HomoloGene9549 GeneCards: CLEC1A Gene
RNA expression pattern
PBB GE CLEC1A 219761 at tn.png
More reference expression data
Species Human Mouse
Entrez 51267 243653
Ensembl ENSG00000150048 ENSMUSG00000033082
UniProt Q8NC01 Q8BWY2
RefSeq (mRNA) NM_001297748 NM_175526
RefSeq (protein) NP_001284677 NP_780735
Location (UCSC) Chr 12:
10.22 – 10.26 Mb
Chr 6:
129.43 – 129.45 Mb
PubMed search [1] [2]

C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.[1][2][3]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[3]


  1. ^ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229. 
  2. ^ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369. 
  3. ^ a b "Entrez Gene: CLEC1A C-type lectin domain family 1, member A". 

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