CLEC1A

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C-type lectin domain family 1, member A
Identifiers
Symbols CLEC1A ; CLEC1
External IDs OMIM606782 MGI2444151 HomoloGene9549 GeneCards: CLEC1A Gene
RNA expression pattern
PBB GE CLEC1A 219761 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51267 243653
Ensembl ENSG00000150048 ENSMUSG00000033082
UniProt Q8NC01 Q8BWY2
RefSeq (mRNA) NM_016511 NM_175526
RefSeq (protein) NP_057595 NP_780735
Location (UCSC) Chr 12:
10.22 – 10.26 Mb
Chr 6:
129.43 – 129.45 Mb
PubMed search [1] [2]

C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.[1][2][3]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[3]

References[edit]

  1. ^ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229. 
  2. ^ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369. 
  3. ^ a b "Entrez Gene: CLEC1A C-type lectin domain family 1, member A". 

Further reading[edit]