CLEC1B

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C-type lectin domain family 1, member B
Protein CLEC1B PDB 2c6u.png
PDB rendering based on 2c6u.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CLEC1B ; 1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721
External IDs OMIM606783 MGI1913287 HomoloGene49468 GeneCards: CLEC1B Gene
RNA expression pattern
PBB GE CLEC1B 220496 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51266 56760
Ensembl ENSG00000165682 ENSMUSG00000030159
UniProt Q9P126 Q9JL99
RefSeq (mRNA) NM_001099431 NM_001204239
RefSeq (protein) NP_001092901 NP_001191168
Location (UCSC) Chr 12:
10.14 – 10.17 Mb
Chr 6:
129.4 – 129.41 Mb
PubMed search [1] [2]

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.[1][2][3]

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM][3]

References[edit]

  1. ^ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229. 
  2. ^ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369. 
  3. ^ a b "Entrez Gene: CLEC1B C-type lectin domain family 1, member B". 

Further reading[edit]