From Wikipedia, the free encyclopedia
Jump to: navigation, search
C-type lectin domain family 1, member B
Protein CLEC1B PDB 2c6u.png
PDB rendering based on 2c6u.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CLEC1B ; 1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721
External IDs OMIM606783 MGI1913287 HomoloGene49468 GeneCards: CLEC1B Gene
RNA expression pattern
PBB GE CLEC1B 220496 at tn.png
More reference expression data
Species Human Mouse
Entrez 51266 56760
Ensembl ENSG00000165682 ENSMUSG00000030159
UniProt Q9P126 Q9JL99
RefSeq (mRNA) NM_001099431 NM_001204239
RefSeq (protein) NP_001092901 NP_001191168
Location (UCSC) Chr 12:
10.14 – 10.17 Mb
Chr 6:
129.4 – 129.41 Mb
PubMed search [1] [2]

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.[1][2][3]

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM][3]


  1. ^ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229. 
  2. ^ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369. 
  3. ^ a b "Entrez Gene: CLEC1B C-type lectin domain family 1, member B". 

Further reading[edit]