C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2Dgene.
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined. CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene.
Iizuka K, Naidenko OV, Plougastel BF, et al. (2003). "Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors". Nat. Immunol.4 (8): 801–7. doi:10.1038/ni954. PMID12858173.
Hu YS, Zhou H, Myers D, et al. (2004). "Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts". J. Bone Miner. Res.19 (1): 89–99. doi:10.1359/JBMR.0301215. PMID14753741.